Triterpenoid saponins from Metadina trichotoma
Zhang, Yu-Mei; Tan, Ning-Hua; Huang, Huo-Qiang; Zeng, Guang-Zhi
AbstractTwo new 27-nor-triterpene glycosides, pyrocincholic acid 3 beta-O-beta-D-glucopyranosyl-(1 -> 4)beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (Metatrichoside A, 1), pyrocincholic acid 3 beta-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-Dglucopyranoside (Metatrichoside B, 2), together with pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (3), pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside (4), quinovic acid 3 beta-O-beta-D-quinovopyranoside (5), quinovic acid 3 beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (6), quinovic acid 3 beta-O-beta-D-glucopyranoside (7) and quinovic acid 3 beta-O-beta-D-glueopyranosyl-28-O-beta-D-glucopyranoside (8) were isolated from the barks of Metadina trichotoma. Their structures were mainly determined by mass spectrometric and 1D and 2D NMR spectroscopic methods. Compound 5 and 6 showed cytotoxic activities towards the A549 non-small-cell lung cancer cell line (IC50 = 8.43 and 6.06 mu m), and the methanol extract inhibited the activity of cathepsin B with an IC50 value of 0.77 mu g mL(-1).
KeywordMetadina Trichotoma Triterpenoid Saponins Metatrichoside a Metatrichoside b
Subject AreaChemistry ; Inorganic & Nuclear ; Chemistry ; Organic
Indexed BySCI ; IC
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear ; Chemistry, Organic
WOS IDWOS:000247299400021
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
AffiliationChinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yu-Mei,Tan, Ning-Hua,Huang, Huo-Qiang,et al. Triterpenoid saponins from Metadina trichotoma[J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,2007,62(5):745-748.
APA Zhang, Yu-Mei,Tan, Ning-Hua,Huang, Huo-Qiang,&Zeng, Guang-Zhi.(2007).Triterpenoid saponins from Metadina trichotoma.ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,62(5),745-748.
MLA Zhang, Yu-Mei,et al."Triterpenoid saponins from Metadina trichotoma".ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES 62.5(2007):745-748.
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