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题名: Triterpenoid saponins from Metadina trichotoma
作者: Zhang, Yu-Mei; Tan, Ning-Hua; Huang, Huo-Qiang; Zeng, Guang-Zhi
刊名: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
关键词: Metadina trichotoma ; triterpenoid saponins ; metatrichoside A ; metatrichoside B
英文摘要: Two new 27-nor-triterpene glycosides, pyrocincholic acid 3 beta-O-beta-D-glucopyranosyl-(1 -> 4)beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (Metatrichoside A, 1), pyrocincholic acid 3 beta-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-Dglucopyranoside (Metatrichoside B, 2), together with pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (3), pyrocincholic acid 3 beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranoside (4), quinovic acid 3 beta-O-beta-D-quinovopyranoside (5), quinovic acid 3 beta-O-beta-D-quinovopyranosyl-28-O-beta-D-glucopyranoside (6), quinovic acid 3 beta-O-beta-D-glucopyranoside (7) and quinovic acid 3 beta-O-beta-D-glueopyranosyl-28-O-beta-D-glucopyranoside (8) were isolated from the barks of Metadina trichotoma. Their structures were mainly determined by mass spectrometric and 1D and 2D NMR spectroscopic methods. Compound 5 and 6 showed cytotoxic activities towards the A549 non-small-cell lung cancer cell line (IC50 = 8.43 and 6.06 mu m), and the methanol extract inhibited the activity of cathepsin B with an IC50 value of 0.77 mu g mL(-1).
出版日期: 2007-05-01
卷号: 62, 期号:5, 页码:745-748
语种: 英语
收录类别: SCI ; IC
学科分类: Chemistry; Inorganic & Nuclear; Chemistry; Organic
ISSN号: 0932-0776
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2073
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Zhang, YM; Tan, NH; Huang, HQ; Zeng, GZ.Triterpenoid saponins from Metadina trichotoma,ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES,2007,62(5):745-748
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