Three new iridoids, jatamanvaltrates R-S (1-2) and jatamanin Q (3), as well as three new sesquiterpenoids, valeriananoids D-E (4,5) and clovane-2 beta-isovaleroxy-9 alpha-ol (6), together with nine known compounds were isolated from the roots of Valeriana jatamansi Jones. Compound 2 was the first reported iridoid with fatty acid esters in the Valerianaceae family. The structures of new compounds were established on the basis of extensive spectroscopic analysis. Moreover, all the isolates were evaluated for inhibitory activity on acetylcholinesterase (AChE). (C) 2015 Elsevier B.V. All rights reserved.
; Pharmacology & Pharmacy
Pharmacology & Pharmacy
OFFICINALIS VAR. LATIFOLIA
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Lijiang Forest Ecosyst Res Stn, Kunming Inst Bot, Kunming 650201, Peoples R China