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题名: Chemical constituents of Swertia mussotii and their anti-hepatitis B virus activity
作者: Cao, Tuan-Wu1; Geng, Chang-An1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Zhou, Jun1; Tao, Yan-Duo2; null(陈纪军)1
刊名: FITOTERAPIA
关键词: Swertia mussotii ; Gentianaceae ; Chemical constituents ; (-)-swermusic acid A and B ; (-)-swerimuslatone A ; Anti-HBV activity
英文摘要: Three new secoiridoid aglycones of (-)-swermusic acid A (1) and B (3), and (-)-swerimuslatone A (2), and four new secoiridoid glycosides of 6'-O-formylsweroside (4),6'-O-formylgentiopicroside (5), 6'-O-acetylamarogentin (6) and 6'-O-acetylamaronitidin (7), along with 40 known compounds (8-47) were isolated from Swertia mussotii. Their structures were elucidated on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Forty-five compounds from S. mussotii were evaluated for their anti-HBV activity on the HepG 2.2.15 cell line in vitro inhibiting the secretions of HBsAg and HBeAg, as well as HBV DNA replication. Six of the nine phenols 26-29,31 and 32 exhibited activities inhibiting HBsAg and HBeAg secretion with IC50 values from 0.23 to 5.18 mM, and HBV DNA replication with IC50 values from <0.06 to 2.62 mM. Moreover, isooriention (45) displayed significant anti-HBV activities against secretions of HBsAg and HBeAg with IC50 value of 0.79 and 1.12 mM, as well as HBV DNA replication with IC50 value of 0.02 mM. (C) 2015 Elsevier B.V. All rights reserved.
出版日期: 2015-04-01
卷号: 102, 页码:15-22
DOI标识: 10.1016/j.fitote.2015.01.020
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20690
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Res Ctr Biol Resources Qinghai Tibet Plateau, Xining 810001, Peoples R China
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