Sweriyunnanlactone A, one unusual secoiridoid trimer from Swertia yunnanensis
Geng, Chang-An; Chen, Xing-Long; Huang, Xiao-Yan; Ma, Yun-Bao; He, Kang; Zhou, Ning-Jia; Cao, Tuan-Wu; Zhang, Xue-Mei; Chen, Ji-Jun
2015-04-22
发表期刊TETRAHEDRON LETTERS
卷号56期号:17页码:2163-2166
摘要One unusual secoiridoid trimer, namely sweriyunnanlactone A (1), was isolated from Swertia yunnanensis under the guidance of LC-MS analysis. Sweriyunnanlactone A with a phenyl ring (ring F) was the first example of secoiridoid trimer featuring a C-28 skeleton. Its structure was determined by extensive HRESIMS, 1D and 2D NMR spectroscopic data, and GIAO C-13 NMR calculation. Compound 1 showed weak inhibition on HBV DNA replication with an IC50 value of 60.76 mu M (SI = 12.6) on HepG 2.2.15 cell line in vitro. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Sweriyunnanlactone a Secoiridoid Trimer Swertia Yunnanensis Lc-ms Guided Isolation Anti-hbv Activity
DOI10.1016/j.tetlet.2015.03.057
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000353745900008
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20689
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
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Geng, Chang-An,Chen, Xing-Long,Huang, Xiao-Yan,et al. Sweriyunnanlactone A, one unusual secoiridoid trimer from Swertia yunnanensis[J]. TETRAHEDRON LETTERS,2015,56(17):2163-2166.
APA Geng, Chang-An.,Chen, Xing-Long.,Huang, Xiao-Yan.,Ma, Yun-Bao.,He, Kang.,...&Chen, Ji-Jun.(2015).Sweriyunnanlactone A, one unusual secoiridoid trimer from Swertia yunnanensis.TETRAHEDRON LETTERS,56(17),2163-2166.
MLA Geng, Chang-An,et al."Sweriyunnanlactone A, one unusual secoiridoid trimer from Swertia yunnanensis".TETRAHEDRON LETTERS 56.17(2015):2163-2166.
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