Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta
Jie, Xiao-Xia1,2,3; Geng, Chang-An3; Huang, Xiao-Yan3; Ma, Yun-Bao3; Zhang, Xue-Mei3; Zhang, Rong-Ping1,2; Chen, Ji-Jun3
2015-04-01
发表期刊FITOTERAPIA
卷号102页码:96-101
摘要Five new secoiridoid glycosides, swericinctosides A and B (1-2), 9-epi swertiamarin (3), 2'-O-m-hydroxybenzoyl swertiamarin (4), 4 ''-O-acetyl swertianoside E (5), and one unusual lactonic enol ketone, 3-(hydroxymethyl ene) dihydro-2H-pyran-2, 4(3H)-dione (6), together with three known compounds, swertiaside (7), swertianoside C (8) and decentapicrin B (9) were isolated from Swertia cincta. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, UV, IR and [alpha](D) spectra. Anti-HBV assay on HepG 22.15 cell line in vitro demonstrated that compounds 1-9 possessed inhibitory activity on HBV DNA replication with IC50 values from 0.05 to 1.83 mM, and compounds 1, 3, 5, 7 and 8 could inhibit the secretion of HBsAg with IC50 values from 024 to 1.06 mM. (C) 2015 Elsevier B.V. All rights reserved.
关键词Swertia Cincta Secoiridoid Glycosides Lactonic Enol Ketone Anti-hbv Activity
DOI10.1016/j.fitote.2015.02.009
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000353742600014
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20685
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
推荐引用方式
GB/T 7714
Jie, Xiao-Xia,Geng, Chang-An,Huang, Xiao-Yan,et al. Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta[J]. FITOTERAPIA,2015,102:96-101.
APA Jie, Xiao-Xia.,Geng, Chang-An.,Huang, Xiao-Yan.,Ma, Yun-Bao.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2015).Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta.FITOTERAPIA,102,96-101.
MLA Jie, Xiao-Xia,et al."Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta".FITOTERAPIA 102(2015):96-101.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S0367326X1500(458KB) 开放获取CC BY-NC-ND请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jie, Xiao-Xia]的文章
[Geng, Chang-An]的文章
[Huang, Xiao-Yan]的文章
百度学术
百度学术中相似的文章
[Jie, Xiao-Xia]的文章
[Geng, Chang-An]的文章
[Huang, Xiao-Yan]的文章
必应学术
必应学术中相似的文章
[Jie, Xiao-Xia]的文章
[Geng, Chang-An]的文章
[Huang, Xiao-Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。