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题名: Five new secoiridoid glycosides and one unusual lactonic enol ketone with anti-HBV activity from Swertia cincta
作者: Jie, Xiao-Xia1, 2, 3; Geng, Chang-An3; Huang, Xiao-Yan3; Ma, Yun-Bao3; Zhang, Xue-Mei3; Zhang, Rong-Ping1, 2; null(陈纪军)3
刊名: FITOTERAPIA
出版日期: 2015-04-01
卷号: 102, 页码:96-101
关键词: Swertia cincta ; Secoiridoid glycosides ; Lactonic enol ketone ; Anti-HBV activity
DOI: 10.1016/j.fitote.2015.02.009
文章类型: Article
英文摘要: Five new secoiridoid glycosides, swericinctosides A and B (1-2), 9-epi swertiamarin (3), 2'-O-m-hydroxybenzoyl swertiamarin (4), 4 ''-O-acetyl swertianoside E (5), and one unusual lactonic enol ketone, 3-(hydroxymethyl ene) dihydro-2H-pyran-2, 4(3H)-dione (6), together with three known compounds, swertiaside (7), swertianoside C (8) and decentapicrin B (9) were isolated from Swertia cincta. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, UV, IR and [alpha](D) spectra. Anti-HBV assay on HepG 22.15 cell line in vitro demonstrated that compounds 1-9 possessed inhibitory activity on HBV DNA replication with IC50 values from 0.05 to 1.83 mM, and compounds 1, 3, 5, 7 and 8 could inhibit the secretion of HBsAg with IC50 values from 024 to 1.06 mM. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CHEMICAL-CONSTITUENTS ; MILEENSIS ; GENTIANACEAE ; ANGUSTIFOLIA ; JAPONICA
收录类别: SCI
语种: 英语
WOS记录号: WOS:000353742600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20685
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China
2.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
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