中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives
作者: Zi, Cheng-Ting1, 2; Yang, Dan2; Dong, Fa-Wu2; Li, Gen-Tao2; null(李艳)2; Ding, Zhong-Tao1; Zhou, Jun2; Jiang, Zi-Hua3; Hu, Jiang-Miao2
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: Podophyllotoxin ; Epipodophyllotoxin ; 4 '-Demethylepipodophyllotoxin ; Butyrylated glycosides ; Antitumor ; Cytotoxic ; Synthesis
英文摘要: A series of perbutyrylated glycosides of podophyllotoxin and its derivatives were synthesized and evaluated for their antitumor activity in vitro. Most of them exhibit cytotoxic activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assays. Among the synthesized compounds, epipodophyllotoxin alpha-D-galactopyranoside 8b, epipodophyllotoxin a-D-arabinopyranoside 8e, and podophyllotoxin beta-D-glucopyranoside 11a show the highest potency of anticancer activity with their IC50 values ranging from 0.14 to 1.69 mu M. Structure activity relationship analysis indicates that the type of glycosidic linkage, the configuration at C-4 of the podophyllotoxin scaffold, and the substitution at 4'-position (OH vs OCH3) can all have significant effect on the potency of their anticancer activity. Several compounds are more active than the control drugs Etoposide and Cisplatin, suggesting their potential as anticancer agents for further development. (C) 2015 Elsevier Ltd. All rights reserved.
出版日期: 2015-04-01
卷号: 23, 期号:7, 页码:1437-1446
DOI标识: 10.1016/j.bmc.2015.02.021
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20630
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Zi-2015-Synthesis and antitumor activity of no.pdf(842KB)----开放获取View Download

作者单位: 1.Yunnan Univ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Lakehead Univ, Dept Chem, Thunder Bay, ON P7B 5E1, Canada
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zi, Cheng-Ting]'s Articles
[Yang, Dan]'s Articles
[Dong, Fa-Wu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zi, Cheng-Ting]‘s Articles
[Yang, Dan]‘s Articles
[Dong, Fa-Wu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Zi-2015-Synthesis and antitumor activity of no.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace