Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives
Zi, Cheng-Ting1,2; Liu, Zhen-Hua2; Li, Gen-Tao2; Li, Yan2; Zhou, Jun2; Ding, Zhong-Tao1; Hu, Jiang-Miao2; Jiang, Zi-Hua3; Ding,ZT (reprint author),Yunnan Univ,Key Lab Med Chem Nat Resource,Minist Educ,Sch Chem Sci & Technol,Kunming 650091,Peoples R China.; zict@sina.cn; liuzhenhua@mail.kib.ac.cn; ligentao@mail.kib.ac.cn; liyanb@mail.kib.ac.cn; jzhou@mail.kib.ac.cn; ztding@ynu.edu.cn; hujiangmiao@mail.kib.ac.cn; zjiang@lakeheadu.ca
2015-02-01
发表期刊MOLECULES
卷号20期号:2页码:3255-3280
摘要A series of novel perbutyrylated glycosides of 4 beta-triazolopodophyllotoxin derivatives were synthesized by utilizing the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Evaluation of cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using the MTT assay shows that some of these glycosylated derivatives have good anticancer activity. Among the synthesized compounds, compound 21a shows the highest activity, with IC50 values ranging from 0.49 to 6.70 mu M, which is more potent than the control drugs etoposide and cisplatin. Compound 21a is characterized by a perbutyrylated alpha-D(+)-galactosyl residue, the absence of an additional linking spacer between the sugar residue and the triazole ring, as well as a 4'-OH group on the E ring of the podophyllotoxin scaffold.
资助信息State Key Laboratory of Phytochemistry and Plant Resource in West China [P2010-KF07]
学科领域Chemistry, Organic
DOI10.3390/molecules20023255
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000350748200086
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20629
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Ding,ZT (reprint author),Yunnan Univ,Key Lab Med Chem Nat Resource,Minist Educ,Sch Chem Sci & Technol,Kunming 650091,Peoples R China.; zict@sina.cn; liuzhenhua@mail.kib.ac.cn; ligentao@mail.kib.ac.cn; liyanb@mail.kib.ac.cn; jzhou@mail.kib.ac.cn; ztding@ynu.edu.cn; hujiangmiao@mail.kib.ac.cn; zjiang@lakeheadu.ca
作者单位1.Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Sch Chem Sci & Technol, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Lakehead Univ, Dept Chem, Thunder Bay, ON P7B 5E1, Canada
推荐引用方式
GB/T 7714
Zi, Cheng-Ting,Liu, Zhen-Hua,Li, Gen-Tao,et al. Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives[J]. MOLECULES,2015,20(2):3255-3280.
APA Zi, Cheng-Ting.,Liu, Zhen-Hua.,Li, Gen-Tao.,Li, Yan.,Zhou, Jun.,...&zjiang@lakeheadu.ca.(2015).Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives.MOLECULES,20(2),3255-3280.
MLA Zi, Cheng-Ting,et al."Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives".MOLECULES 20.2(2015):3255-3280.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Zi-2015-Design, Synt(910KB) 开放获取CC BY-NC-ND请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zi, Cheng-Ting]的文章
[Liu, Zhen-Hua]的文章
[Li, Gen-Tao]的文章
百度学术
百度学术中相似的文章
[Zi, Cheng-Ting]的文章
[Liu, Zhen-Hua]的文章
[Li, Gen-Tao]的文章
必应学术
必应学术中相似的文章
[Zi, Cheng-Ting]的文章
[Liu, Zhen-Hua]的文章
[Li, Gen-Tao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。