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题名: Anti-hepatitis B virus active constituents from Swertia chirayita
作者: Zhou, Ning-Jia1, 3; Geng, Chang-An1; Huang, Xiao-Yan1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Wang, Ju-Le2; null(陈纪军)1
刊名: FITOTERAPIA
出版日期: 2015
卷号: 100, 页码:27-34
关键词: Swertiachiralatone A ; Swertiachoside A ; Swertiachirdiol A ; Swertiachoside B ; Anti-hepatitis B virus activity ; Swertia chirayita
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
DOI: 10.1016/j.fitote.2014.11.011
通讯作者: Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; chenjj@mail.kib.ac.cn
文章类型: Article
英文摘要: Four new compounds swerdachiralatone A (1), swertiachoside A (2), swertiachirdiol A (3) and swertiachoside B (4), together with twenty-six known ones were isolated from the ethanol extract of Swertia chirayita. Their structures were elucidated by extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR and [alpha](D)). All compounds were evaluated for anti-hepatitis B virus (anti-HBV) activities on HepG 2.2.15 cells line in vitro, of which compounds 14 and 19 showed inhibitory activity on hepatitis B surface antigen (HBsAg) secretion with IC50 values of 031 +/- 0.045 and 1.49 +/- 0.033 mM; compounds 14 and 28 exhibited activity against hepatitis Be antigen (HBeAg) secretion with IC50 values of 0.77 +/- 0.076 and 5.92 +/- 1.02 mM; and eight compounds (8,9,13,14,24-26,29) possessed activity against HBV DNA replication with IC50 values of 0.07-033 mM. In particular (+)-cycloolivil-4'-O-beta-D-glucopyranoside (14) exhibited inhibition not only on the secretions of HBsAg and HBeAg with IC50 values of 031 +/- 0.045 mM (SI = 4.29) and 0.77 +/- 0.076 mM (SI = 1.75), respectively, but also on HBV DNA replication with an IC50 value of 029 +/- 0.034 mM (SI = 4.66). (C) 2014 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: FATTY-ACID ESTER ; CHIRATA BUCH-HAM ; HEPATOPROTECTIVE AGENT ; CHEMICAL-CONSTITUENTS ; GLYCOSIDES ; XANTHONE ; TRITERPENOIDS ; LIGNAN
收录类别: SCI
项目资助者: International Foundation for Science in Sweden [F/5202-1] ; National Natural Science Foundation of China for Distinguished Young Scholars [81025023] ; West Light Foundation of the Chinese Academy of Sciences ; National Natural Science Foundation of China [81202436] ; Youth Innovation Promotion Association, CAS
语种: 英语
WOS记录号: WOS:000349881300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20627
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Tibet Univ, Sch Med, Lhasa 850000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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