Anti-hepatitis B virus active constituents from Swertia chirayita
Zhou, Ning-Jia1,3; Geng, Chang-An1; Huang, Xiao-Yan1; Ma, Yun-Bao1; Zhang, Xue-Mei1; Wang, Ju-Le2; Chen, Ji-Jun1; Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; chenjj@mail.kib.ac.cn
2015
发表期刊FITOTERAPIA
卷号100页码:27-34
摘要Four new compounds swerdachiralatone A (1), swertiachoside A (2), swertiachirdiol A (3) and swertiachoside B (4), together with twenty-six known ones were isolated from the ethanol extract of Swertia chirayita. Their structures were elucidated by extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR and [alpha](D)). All compounds were evaluated for anti-hepatitis B virus (anti-HBV) activities on HepG 2.2.15 cells line in vitro, of which compounds 14 and 19 showed inhibitory activity on hepatitis B surface antigen (HBsAg) secretion with IC50 values of 031 +/- 0.045 and 1.49 +/- 0.033 mM; compounds 14 and 28 exhibited activity against hepatitis Be antigen (HBeAg) secretion with IC50 values of 0.77 +/- 0.076 and 5.92 +/- 1.02 mM; and eight compounds (8,9,13,14,24-26,29) possessed activity against HBV DNA replication with IC50 values of 0.07-033 mM. In particular (+)-cycloolivil-4'-O-beta-D-glucopyranoside (14) exhibited inhibition not only on the secretions of HBsAg and HBeAg with IC50 values of 031 +/- 0.045 mM (SI = 4.29) and 0.77 +/- 0.076 mM (SI = 1.75), respectively, but also on HBV DNA replication with an IC50 value of 029 +/- 0.034 mM (SI = 4.66). (C) 2014 Elsevier B.V. All rights reserved.
关键词Swertiachiralatone a Swertiachoside a Swertiachirdiol a Swertiachoside b Anti-hepatitis b Virus Activity Swertia Chirayita
资助信息International Foundation for Science in Sweden [F/5202-1]; National Natural Science Foundation of China for Distinguished Young Scholars [81025023]; West Light Foundation of the Chinese Academy of Sciences; National Natural Science Foundation of China [81202436]; Youth Innovation Promotion Association, CAS
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2014.11.011
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000349881300005
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20627
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; chenjj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Tibet Univ, Sch Med, Lhasa 850000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhou, Ning-Jia,Geng, Chang-An,Huang, Xiao-Yan,et al. Anti-hepatitis B virus active constituents from Swertia chirayita[J]. FITOTERAPIA,2015,100:27-34.
APA Zhou, Ning-Jia.,Geng, Chang-An.,Huang, Xiao-Yan.,Ma, Yun-Bao.,Zhang, Xue-Mei.,...&chenjj@mail.kib.ac.cn.(2015).Anti-hepatitis B virus active constituents from Swertia chirayita.FITOTERAPIA,100,27-34.
MLA Zhou, Ning-Jia,et al."Anti-hepatitis B virus active constituents from Swertia chirayita".FITOTERAPIA 100(2015):27-34.
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