The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats
Yu,Dafu; Zhou,Heng; Yang,Yuan; Jiang,Yong; Wang,Tianchao; Lv,Liang; Zhou,Qixin; Yang,Yuexiong; Dong,Xuexian; He,Jianfeng; Huang,Xiaoyan; Chen,Jijun; Wu,Kunhua; Xu,Lin; Mao,Rongrong; Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China.; lxu@vip.163.com; talktomaomao@163.com
2015
发表期刊HORMONES AND BEHAVIOR
卷号69期号:1页码:106-115
摘要

Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine (I-131) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of I-131 (5 mCi/kg). These.rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15 mu g/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxietyand depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15 mg/kg) diminished serum FT4 levels as well as anxietyand depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels. (C) 2015 Elsevier Inc. All rights reserved.

关键词Hypothyroidism Hyperthyroidism Depression Anxiety Brain-derived Neurotrophic Factor
学科领域Behavioral Sciences ; Endocrinology & Metabolism
DOI10.1016/j.yhbeh.2015.01.003
收录类别SCI
语种英语
WOS记录号WOS:000352118500012
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20624
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China.; lxu@vip.163.com; talktomaomao@163.com
推荐引用方式
GB/T 7714
Yu,Dafu,Zhou,Heng,Yang,Yuan,et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J]. HORMONES AND BEHAVIOR,2015,69(1):106-115.
APA Yu,Dafu.,Zhou,Heng.,Yang,Yuan.,Jiang,Yong.,Wang,Tianchao.,...&talktomaomao@163.com.(2015).The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.HORMONES AND BEHAVIOR,69(1),106-115.
MLA Yu,Dafu,et al."The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats".HORMONES AND BEHAVIOR 69.1(2015):106-115.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yu-2015-The bidirect(867KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yu,Dafu]的文章
[Zhou,Heng]的文章
[Yang,Yuan]的文章
百度学术
百度学术中相似的文章
[Yu,Dafu]的文章
[Zhou,Heng]的文章
[Yang,Yuan]的文章
必应学术
必应学术中相似的文章
[Yu,Dafu]的文章
[Zhou,Heng]的文章
[Yang,Yuan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Yu-2015-The bidirectional effects of hypothyro.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。