The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats
Yu,Dafu; Zhou,Heng; Yang,Yuan; Jiang,Yong; Wang,Tianchao; Lv,Liang; Zhou,Qixin; Yang,Yuexiong; Dong,Xuexian; He,Jianfeng; Huang,Xiaoyan; Chen,Jijun; Wu,Kunhua; Xu,Lin; Mao,Rongrong; Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China.; lxu@vip.163.com; talktomaomao@163.com
2015
Source PublicationHORMONES AND BEHAVIOR
Volume69Issue:1Pages:106-115
Abstract

Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine (I-131) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of I-131 (5 mCi/kg). These.rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15 mu g/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxietyand depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15 mg/kg) diminished serum FT4 levels as well as anxietyand depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels. (C) 2015 Elsevier Inc. All rights reserved.

KeywordHypothyroidism Hyperthyroidism Depression Anxiety Brain-derived Neurotrophic Factor
Subject AreaBehavioral Sciences ; Endocrinology & Metabolism
DOI10.1016/j.yhbeh.2015.01.003
Indexed BySCI
Language英语
WOS Research AreaBehavioral Sciences ; Endocrinology & Metabolism
WOS IDWOS:000352118500012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20624
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorXu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China.; lxu@vip.163.com; talktomaomao@163.com
Recommended Citation
GB/T 7714
Yu,Dafu,Zhou,Heng,Yang,Yuan,et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J]. HORMONES AND BEHAVIOR,2015,69(1):106-115.
APA Yu,Dafu.,Zhou,Heng.,Yang,Yuan.,Jiang,Yong.,Wang,Tianchao.,...&talktomaomao@163.com.(2015).The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.HORMONES AND BEHAVIOR,69(1),106-115.
MLA Yu,Dafu,et al."The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats".HORMONES AND BEHAVIOR 69.1(2015):106-115.
Files in This Item: Download All
File Name/Size DocType Version Access License
Yu-2015-The bidirect(867KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yu,Dafu]'s Articles
[Zhou,Heng]'s Articles
[Yang,Yuan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yu,Dafu]'s Articles
[Zhou,Heng]'s Articles
[Yang,Yuan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yu,Dafu]'s Articles
[Zhou,Heng]'s Articles
[Yang,Yuan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Yu-2015-The bidirectional effects of hypothyro.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.