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题名: The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats
作者: Yu,Dafu ; Zhou,Heng ; Yang,Yuan ; Jiang,Yong ; Wang,Tianchao ; Lv,Liang ; Zhou,Qixin ; Yang,Yuexiong ; Dong,Xuexian ; He,Jianfeng ; Huang,Xiaoyan ; Chen,Jijun ; Wu,Kunhua ; Xu,Lin ; Mao,Rongrong
刊名: HORMONES AND BEHAVIOR
出版日期: 2015
卷号: 69, 页码:106-115
关键词: Hypothyroidism ; Hyperthyroidism ; Depression ; Anxiety ; Brain-derived neurotrophic factor
学科分类: Behavioral Sciences; Endocrinology & Metabolism
DOI: 10.1016/j.yhbeh.2015.01.003
通讯作者: Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China. ; lxu@vip.163.com ; talktomaomao@163.com
文章类型: Article
英文摘要: Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine (I-131) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of I-131 (5 mCi/kg). These.rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15 mu g/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxietyand depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15 mg/kg) diminished serum FT4 levels as well as anxietyand depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels. (C) 2015 Elsevier Inc. All rights reserved.
研究领域[WOS]: Behavioral Sciences ; Endocrinology & Metabolism
关键词[WOS]: ADULT HIPPOCAMPAL NEUROGENESIS ; FORCED SWIMMING TEST ; THYROID-HORMONES ; GRAVES-DISEASE ; ANTIDEPRESSANT TREATMENTS ; FOOD-INTAKE ; PLUS-MAZE ; BRAIN ; TRIIODOTHYRONINE ; SEROTONIN
收录类别: SCI
项目资助者: 973 Project [2013CB835103] ; NSFC-CIHR [81161120536] ; Chinese Academy of Sciences [XDB0202002] ; NSFC [31100786, U1032605, U1132602, 81171294] ; Science and Technology Program of Yunnan Province [2013GA003, 2010CD104] ; Chinese Human Resources and Social Security Department [508]
语种: 英语
WOS记录号: WOS:000352118500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20624
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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