The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats
Yu,Dafu; Zhou,Heng; Yang,Yuan; Jiang,Yong; Wang,Tianchao; Lv,Liang; Zhou,Qixin; Yang,Yuexiong; Dong,Xuexian; He,Jianfeng; Huang,Xiaoyan; Chen,Jijun; Wu,Kunhua; Xu,Lin; Mao,Rongrong; Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China.; lxu@vip.163.com; talktomaomao@163.com
2015
发表期刊HORMONES AND BEHAVIOR
卷号69页码:106-115
摘要Thyroid hormone disorders have long been linked to depression, but the causal relationship between them remains controversial. To address this question, we established rat models of hypothyroidism using (131)iodine (I-131) and hyperthyroidism using levothyroxine (LT4). Serum free thyroxine (FT4) and triiodothyronine (FT3) significantly decreased in the hypothyroid of rats with single injections of I-131 (5 mCi/kg). These.rats exhibited decreased depression-like behaviors in forced swimming test and sucrose preference tests, as well as decreased anxiety-like behaviors in an elevated plus maze. Diminished levels of brain serotonin (5-HT) and increased levels of hippocampal brain-derived neurotrophic factor (BDNF) were found in the hypothyroid rats compared to the control saline-vehicle administered rats. LT4 treatment reversed the decrease in thyroid hormones and depression-like behaviors. In contrast, hyperthyroidism induced by weekly injections of LT4 (15 mu g/kg) caused a greater than 10-fold increase in serum FT4 and FT3 levels. The hyperthyroid rats exhibited higher anxietyand depression-like behaviors, higher brain 5-HT level, and lower hippocampal BDNF levels than the controls. Treatment with the antidepressant imipramine (15 mg/kg) diminished serum FT4 levels as well as anxietyand depression-like behaviors in the hyperthyroid rats but led to a further increase in brain 5-HT levels, compared with the controls or the hypothyroid rats. Together, our results suggest that hypothyroidism and hyperthyroidism have bidirectional effects on anxiety- and depression-like behaviors in rats, possibly by modulating hippocampal BDNF levels. (C) 2015 Elsevier Inc. All rights reserved.
关键词Hypothyroidism Hyperthyroidism Depression Anxiety Brain-derived Neurotrophic Factor
资助信息973 Project [2013CB835103]; NSFC-CIHR [81161120536]; Chinese Academy of Sciences [XDB0202002]; NSFC [31100786, U1032605, U1132602, 81171294]; Science and Technology Program of Yunnan Province [2013GA003, 2010CD104]; Chinese Human Resources and Social Security Department [508]
学科领域Behavioral Sciences ; Endocrinology & Metabolism
DOI10.1016/j.yhbeh.2015.01.003
收录类别SCI
语种英语
WOS研究方向Behavioral Sciences ; Endocrinology & Metabolism
WOS记录号WOS:000352118500012
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20624
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Xu,L (reprint author),Chinese Acad Sci,Kunming Inst Zool,Lab Learning & Memory,Kunming 650223,Yunnan,Peoples R China.; lxu@vip.163.com; talktomaomao@163.com
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Yu,Dafu,Zhou,Heng,Yang,Yuan,et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats[J]. HORMONES AND BEHAVIOR,2015,69:106-115.
APA Yu,Dafu.,Zhou,Heng.,Yang,Yuan.,Jiang,Yong.,Wang,Tianchao.,...&talktomaomao@163.com.(2015).The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.HORMONES AND BEHAVIOR,69,106-115.
MLA Yu,Dafu,et al."The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats".HORMONES AND BEHAVIOR 69(2015):106-115.
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