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题名: Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice
作者: Yao, Ran1, 2; Chen, Zhaoli1, 2; Zhou, Chengcheng1, 2; Luo, Mei1, 2; Shi, Xuejiao1, 2; Li, Jiagen1, 2; Gao, Yibo1, 2; Zhou, Fang1, 2; Pu, Jianxin3; null(孙汉董)3; He, Jie1, 2
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: Esophageal cancer is the eighth most common cancer in the world and ranks as the sixth leading cause of cancer-related mortality. Esophageal cancer has a poor prognosis partially due to its low sensitivity to chemotherapy agents, and the development of new therapeutic agents is urgently needed. Here, the antitumor activity of a natural ent-kaurane diterpenoid, xerophilusin B (1), which was isolated from Isodon xerophilus, a perennial herb frequently used in Chinese folk medicine for tumor treatment, was investigated. Compound 1 exhibited antiproliferative effects against esophageal squamous cell carcinoma (ESCC) cell lines in a time- and dose-dependent manner with lower toxicity against normal human and murine cell lines. In vivo studies demonstrated that 1 inhibited tumor growth of a human esophageal tumor xenograft in BALB/c nude mice without significant secondary adverse effects, indicating its safety in treating ESCC. Furthermore, 1 induced G2/M cell cycle arrest and promoted apoptosis through mitochondrial cytochrome c-dependent activation of the caspase-9 and caspase-3 cascade pathway in ESCC cell lines. In conclusion, the observations herein reported showed that 1 is a potential chemotherapeutic agent for ESCC and merits further preclinical and clinical investigation for cancer drug development.
出版日期: 2015
卷号: 78, 期号:1, 页码:10-16
DOI标识: 10.1021/np500429w
语种: 英语
收录类别: SCI
学科分类: Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20622
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Peking Union Med Coll, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Beijing 100021, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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