Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice
Yao, Ran1,2; Chen, Zhaoli1,2; Zhou, Chengcheng1,2; Luo, Mei1,2; Shi, Xuejiao1,2; Li, Jiagen1,2; Gao, Yibo1,2; Zhou, Fang1,2; Pu, Jianxin3; Sun, Handong3; He, Jie1,2; Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; pujianxin@mail.kib.ac.cn; prof_jiehe@163.com
2015
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号78期号:1页码:10-16
摘要Esophageal cancer is the eighth most common cancer in the world and ranks as the sixth leading cause of cancer-related mortality. Esophageal cancer has a poor prognosis partially due to its low sensitivity to chemotherapy agents, and the development of new therapeutic agents is urgently needed. Here, the antitumor activity of a natural ent-kaurane diterpenoid, xerophilusin B (1), which was isolated from Isodon xerophilus, a perennial herb frequently used in Chinese folk medicine for tumor treatment, was investigated. Compound 1 exhibited antiproliferative effects against esophageal squamous cell carcinoma (ESCC) cell lines in a time- and dose-dependent manner with lower toxicity against normal human and murine cell lines. In vivo studies demonstrated that 1 inhibited tumor growth of a human esophageal tumor xenograft in BALB/c nude mice without significant secondary adverse effects, indicating its safety in treating ESCC. Furthermore, 1 induced G2/M cell cycle arrest and promoted apoptosis through mitochondrial cytochrome c-dependent activation of the caspase-9 and caspase-3 cascade pathway in ESCC cell lines. In conclusion, the observations herein reported showed that 1 is a potential chemotherapeutic agent for ESCC and merits further preclinical and clinical investigation for cancer drug development.
资助信息Chinese National Natural Science Joint Foundation of Yunnan Province [U1302223]; National Natural Science Foundation of China [21322204, 81172939, 81172336]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np500429w
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000348617800003
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20622
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; pujianxin@mail.kib.ac.cn; prof_jiehe@163.com
作者单位1.Peking Union Med Coll, Canc Inst & Hosp, Dept Thorac Surg, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Beijing 100021, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Yao, Ran,Chen, Zhaoli,Zhou, Chengcheng,et al. Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(1):10-16.
APA Yao, Ran.,Chen, Zhaoli.,Zhou, Chengcheng.,Luo, Mei.,Shi, Xuejiao.,...&prof_jiehe@163.com.(2015).Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice.JOURNAL OF NATURAL PRODUCTS,78(1),10-16.
MLA Yao, Ran,et al."Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice".JOURNAL OF NATURAL PRODUCTS 78.1(2015):10-16.
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