Five 3,4-seco-cycloartane triterpenoids were isolated from the stems of Kadsura ananosma, two of which had rearranged 5/6 consecutive carbocycle rings C/D (trivially named ananosins A (1) and B (2)), one had a migrated CH3-18 (named ananosins C (3)), and two were analogs, ananosins D (4) and E (5). Their structures were characterized by comprehensive spectroscopic analysis, especially using 2D NMR spectra. A biogenetic pathway to 1 was proposed. These 5 compounds, together with 5 known analogs isolated from the same origin, were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, PANC-1, and SK-BR-3 human cancer cells, but were inactive, (C) 2014 Elsevier Ltd. All rights reserved.
National Natural Science Foundation of China 
; Major State Basic Research Development Program of China [2009CB522300, 2009CB940900]
; Young Academic and Technical Leader Rising Foundation of Yunnan Province
; Science and technology plan project of Yunnan Province [2008GA031]
; CAS action-plan for West Development [KZCX2-XB2-15]