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题名: Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives
作者: Xu,Xiao-Liang ; Yu,Chun-Lei ; Chen,Wen ; Li,Ying-Chao ; Yang,Li-Juan ; null(李艳) ; Zhang,Hong-Bin ; Yang,Xiao-Dong
刊名: ORGANIC & BIOMOLECULAR CHEMISTRY
英文摘要: A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 mu M, and exhibited cytotoxic activity selectively against MCF-7, SW480, SMMC-7721 and HL-60 cell lines, while compound 26 showed powerful inhibitory activities selectively against SMMC-7721 and A549 cell lines. Compound 25 can induce G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells.
出版日期: 2015
卷号: 13, 期号:5, 页码:1550-1557
语种: 英语
收录类别: SCI
学科分类: Chemistry, Organic
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20617
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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