| Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives | |
Xu,Xiao-Liang; Yu,Chun-Lei; Chen,Wen; Li,Ying-Chao; Yang,Li-Juan; Li,Yan ; Zhang,Hong-Bin; Yang,Xiao-Dong; Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; liyanb@mail.kib.ac.cn; zhanghbyd@gmail.com; xdyang@ynu.edu.cn
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| 2015 | |
| Source Publication | ORGANIC & BIOMOLECULAR CHEMISTRY
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| Volume | 13Issue:5Pages:1550-1557 |
| Abstract | A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 mu M, and exhibited cytotoxic activity selectively against MCF-7, SW480, SMMC-7721 and HL-60 cell lines, while compound 26 showed powerful inhibitory activities selectively against SMMC-7721 and A549 cell lines. Compound 25 can induce G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells. |
| Subject Area | Chemistry, Organic |
| DOI | 10.1039/c4ob02385d |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS ID | WOS:000348212300033 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/20617 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; liyanb@mail.kib.ac.cn; zhanghbyd@gmail.com; xdyang@ynu.edu.cn |
| Recommended Citation GB/T 7714 | Xu,Xiao-Liang,Yu,Chun-Lei,Chen,Wen,et al. Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(5):1550-1557. |
| APA | Xu,Xiao-Liang.,Yu,Chun-Lei.,Chen,Wen.,Li,Ying-Chao.,Yang,Li-Juan.,...&xdyang@ynu.edu.cn.(2015).Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,13(5),1550-1557. |
| MLA | Xu,Xiao-Liang,et al."Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 13.5(2015):1550-1557. |
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