Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives
Xu,Xiao-Liang; Yu,Chun-Lei; Chen,Wen; Li,Ying-Chao; Yang,Li-Juan; Li,Yan; Zhang,Hong-Bin; Yang,Xiao-Dong; Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; liyanb@mail.kib.ac.cn; zhanghbyd@gmail.com; xdyang@ynu.edu.cn
2015
发表期刊ORGANIC & BIOMOLECULAR CHEMISTRY
卷号13期号:5页码:1550-1557
摘要A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 mu M, and exhibited cytotoxic activity selectively against MCF-7, SW480, SMMC-7721 and HL-60 cell lines, while compound 26 showed powerful inhibitory activities selectively against SMMC-7721 and A549 cell lines. Compound 25 can induce G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells.
资助信息Program for Changjiang Scholars and Innovative Research Team in University [IRT13095]; Natural Science Foundation of China [21462049, 21332007, U1402227]; Natural Science Foundation of Yunnan Province [2013FA028, 2012FB113, 2010GA014]; Natural Science Foundation of Education Department of Yunnan Province [ZD2014010]; Project of Recruited Top Talent of Sciences and Technology of Yunnan Province [2009C1120]; 100 Talents Program of CAS
学科领域Chemistry, Organic
DOI10.1039/c4ob02385d
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000348212300033
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20617
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; liyanb@mail.kib.ac.cn; zhanghbyd@gmail.com; xdyang@ynu.edu.cn
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Xu,Xiao-Liang,Yu,Chun-Lei,Chen,Wen,et al. Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(5):1550-1557.
APA Xu,Xiao-Liang.,Yu,Chun-Lei.,Chen,Wen.,Li,Ying-Chao.,Yang,Li-Juan.,...&xdyang@ynu.edu.cn.(2015).Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,13(5),1550-1557.
MLA Xu,Xiao-Liang,et al."Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 13.5(2015):1550-1557.
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