Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives
Xu,Xiao-Liang; Yu,Chun-Lei; Chen,Wen; Li,Ying-Chao; Yang,Li-Juan; Li,Yan; Zhang,Hong-Bin; Yang,Xiao-Dong; Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; liyanb@mail.kib.ac.cn; zhanghbyd@gmail.com; xdyang@ynu.edu.cn
2015
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
Volume13Issue:5Pages:1550-1557
AbstractA series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 mu M, and exhibited cytotoxic activity selectively against MCF-7, SW480, SMMC-7721 and HL-60 cell lines, while compound 26 showed powerful inhibitory activities selectively against SMMC-7721 and A549 cell lines. Compound 25 can induce G2/M phase cell cycle arrest and apoptosis in SMMC-7721 cells.
Subject AreaChemistry, Organic
DOI10.1039/c4ob02385d
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS IDWOS:000348212300033
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20617
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; liyanb@mail.kib.ac.cn; zhanghbyd@gmail.com; xdyang@ynu.edu.cn
Recommended Citation
GB/T 7714
Xu,Xiao-Liang,Yu,Chun-Lei,Chen,Wen,et al. Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2015,13(5):1550-1557.
APA Xu,Xiao-Liang.,Yu,Chun-Lei.,Chen,Wen.,Li,Ying-Chao.,Yang,Li-Juan.,...&xdyang@ynu.edu.cn.(2015).Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.ORGANIC & BIOMOLECULAR CHEMISTRY,13(5),1550-1557.
MLA Xu,Xiao-Liang,et al."Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives".ORGANIC & BIOMOLECULAR CHEMISTRY 13.5(2015):1550-1557.
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