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题名: Galiellalactone analogs and their possible precursors from Sarcosomataceae
作者: Tian, Jie-Feng1; Yu, Ru-Jian2; Li, Xiao-Xia2; Gao, Hao2; Guo, Liang-Dong3; null(李艳)4; Li, Jia5, 6; Tang, Jin-Shan2; Yao, Xin-Sheng1, 2
刊名: FITOTERAPIA
关键词: Sarcosomataceae ; Chemical constituents ; Galiellalactone analogs ; Pregaliellalactone analogs ; Cytotoxicity
英文摘要: Galiellalactone analogs (1-4) (including two new compounds), together with their possible precursors (5-9, named pregaliellalactone B-F), were obtained from the solid cultures of an endophytic fungus Sarcosomataceae NO.45-1-8-1. Their chemical structures were elucidated by analyses of HR ESI-TOF MS, 1D-, 2D-NMR, CD spectra and single crystal X-ray diffraction methods. Compounds 5-9, the possible precursors of galiellalactbne analogs, were found to exist as enantiomers for the first time. The cytotoxicity of these compounds against six tumor cell lines was examined and preliminary structure-activity relationship (SAR) was also discussed. (C) 2015 Elsevier B.V. All rights reserved.
出版日期: 2015-03-01
卷号: 101, 页码:92-98
DOI标识: 10.1016/j.fitote.2015.01.002
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20609
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
2.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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