Galiellalactone analogs and their possible precursors from Sarcosomataceae
Tian, Jie-Feng1; Yu, Ru-Jian2; Li, Xiao-Xia2; Gao, Hao2; Guo, Liang-Dong3; Li, Yan4; Li, Jia5,6; Tang, Jin-Shan2; Yao, Xin-Sheng1,2; Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,601 Huangpu Ave West,Guangzhou 510632,Guangdong,Peoples R China.; gztangjinshan@126.com; tyaoxs@jnu.edu.cn
2015-03-01
发表期刊FITOTERAPIA
卷号101页码:92-98
摘要Galiellalactone analogs (1-4) (including two new compounds), together with their possible precursors (5-9, named pregaliellalactone B-F), were obtained from the solid cultures of an endophytic fungus Sarcosomataceae NO.45-1-8-1. Their chemical structures were elucidated by analyses of HR ESI-TOF MS, 1D-, 2D-NMR, CD spectra and single crystal X-ray diffraction methods. Compounds 5-9, the possible precursors of galiellalactbne analogs, were found to exist as enantiomers for the first time. The cytotoxicity of these compounds against six tumor cell lines was examined and preliminary structure-activity relationship (SAR) was also discussed. (C) 2015 Elsevier B.V. All rights reserved.
关键词Sarcosomataceae Chemical Constituents Galiellalactone Analogs Pregaliellalactone Analogs Cytotoxicity
资助信息Ministry of Science and Technology of China [2012ZX09301002003]; Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]; program for New Century Excellent Talents in University [NCET-10-0120]; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2015.01.002
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000352252700013
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20609
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,601 Huangpu Ave West,Guangzhou 510632,Guangdong,Peoples R China.; gztangjinshan@126.com; tyaoxs@jnu.edu.cn
作者单位1.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
2.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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Tian, Jie-Feng,Yu, Ru-Jian,Li, Xiao-Xia,et al. Galiellalactone analogs and their possible precursors from Sarcosomataceae[J]. FITOTERAPIA,2015,101:92-98.
APA Tian, Jie-Feng.,Yu, Ru-Jian.,Li, Xiao-Xia.,Gao, Hao.,Guo, Liang-Dong.,...&tyaoxs@jnu.edu.cn.(2015).Galiellalactone analogs and their possible precursors from Sarcosomataceae.FITOTERAPIA,101,92-98.
MLA Tian, Jie-Feng,et al."Galiellalactone analogs and their possible precursors from Sarcosomataceae".FITOTERAPIA 101(2015):92-98.
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