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题名: Galiellalactone analogs and their possible precursors from Sarcosomataceae
作者: Tian, Jie-Feng1; Yu, Ru-Jian2; Li, Xiao-Xia2; Gao, Hao2; Guo, Liang-Dong3; null(李艳)4; Li, Jia5, 6; Tang, Jin-Shan2; Yao, Xin-Sheng1, 2
刊名: FITOTERAPIA
出版日期: 2015-03-01
卷号: 101, 页码:92-98
关键词: Sarcosomataceae ; Chemical constituents ; Galiellalactone analogs ; Pregaliellalactone analogs ; Cytotoxicity
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
DOI: 10.1016/j.fitote.2015.01.002
通讯作者: Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,601 Huangpu Ave West,Guangzhou 510632,Guangdong,Peoples R China. ; gztangjinshan@126.com ; tyaoxs@jnu.edu.cn
文章类型: Article
英文摘要: Galiellalactone analogs (1-4) (including two new compounds), together with their possible precursors (5-9, named pregaliellalactone B-F), were obtained from the solid cultures of an endophytic fungus Sarcosomataceae NO.45-1-8-1. Their chemical structures were elucidated by analyses of HR ESI-TOF MS, 1D-, 2D-NMR, CD spectra and single crystal X-ray diffraction methods. Compounds 5-9, the possible precursors of galiellalactbne analogs, were found to exist as enantiomers for the first time. The cytotoxicity of these compounds against six tumor cell lines was examined and preliminary structure-activity relationship (SAR) was also discussed. (C) 2015 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ACTIVE SECONDARY METABOLITES ; ASCOMYCETE A111-95 ; INHIBITION ; CELLS ; RUFA
收录类别: SCI
项目资助者: Ministry of Science and Technology of China [2012ZX09301002003] ; Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287] ; program for New Century Excellent Talents in University [NCET-10-0120] ; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
语种: 英语
WOS记录号: WOS:000352252700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20609
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China
2.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Photochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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