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题名: Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity
作者: Tang,Jian-Jun ; Fang,Ping ; Xia,Hou-Lin ; Tu,Zheng-Chao ; Hou,Bi-Yu ; Yan,Yong-Ming ; Di,Lei ; Zhang,Li ; null(程永现)
刊名: FOOD RESEARCH INTERNATIONAL
关键词: Polyrhachis dives ; Formicidae ; Chinese black ants ; Diabetic nephropathy ; Alkaloids
英文摘要: Accumulated data have emphasized the critical role of inflammation in the pathogenesis of diabetic nephropathy (DN). Chinese black ants (Polyrhachis dives), an edible insect, are well-known for kidney tonifying and anti-inflammatory properties. We have conducted a study that led to isolation of thirteen nonpeptide nitrogen containing compounds from P. dives. Most of these substances possess pyridine moieties and three are alkaloids isolated for the first time from natural sources. Based on ethnopharmacological considerations, the biological potentials of these substances were determined utilizing multiple assays including renal protection, T-, B-lymphocyte proliferation, TNF-alpha, COX-1, COX-2, and Jak3 kinase inhibition. The finding that several members of this family display activities in one or more of these assays has led to the elucidation of part of the chemical profile of P. dives in terms of non-peptide, small-molecule components. (C) 2014 Elsevier Ltd. All rights reserved.
出版日期: 2015
卷号: 67, 页码:163-168
DOI标识: 10.1016/j.foodres.2014.11.022
语种: 英语
收录类别: SCI
学科分类: Food Science & Technology
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20608
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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