Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity
Tang,Jian-Jun; Fang,Ping; Xia,Hou-Lin; Tu,Zheng-Chao; Hou,Bi-Yu; Yan,Yong-Ming; Di,Lei; Zhang,Li; Cheng,Yong-Xian; Zhang,L (reprint author),132 Lanhei Rd,Kunming 650201,Peoples R China.; zhangli@imm.ac.cn; yxcheng@mail.kib.ac.cn
2015
发表期刊FOOD RESEARCH INTERNATIONAL
卷号67页码:163-168
摘要Accumulated data have emphasized the critical role of inflammation in the pathogenesis of diabetic nephropathy (DN). Chinese black ants (Polyrhachis dives), an edible insect, are well-known for kidney tonifying and anti-inflammatory properties. We have conducted a study that led to isolation of thirteen nonpeptide nitrogen containing compounds from P. dives. Most of these substances possess pyridine moieties and three are alkaloids isolated for the first time from natural sources. Based on ethnopharmacological considerations, the biological potentials of these substances were determined utilizing multiple assays including renal protection, T-, B-lymphocyte proliferation, TNF-alpha, COX-1, COX-2, and Jak3 kinase inhibition. The finding that several members of this family display activities in one or more of these assays has led to the elucidation of part of the chemical profile of P. dives in terms of non-peptide, small-molecule components. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Polyrhachis Dives Formicidae Chinese Black Ants Diabetic Nephropathy Alkaloids
资助信息Open Research Fund of State Key Laboratory Breeding Base of Systematic Research; Development and Utilization of Chinese Medicine Resources; Young and Middle Aged Academic Leaders of Kunming; Center of Cooperative Innovation for South China Medicine of Yunnan Province
学科领域Food Science & Technology
DOI10.1016/j.foodres.2014.11.022
收录类别SCI
语种英语
WOS研究方向Food Science & Technology
WOS记录号WOS:000348619600019
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20608
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zhang,L (reprint author),132 Lanhei Rd,Kunming 650201,Peoples R China.; zhangli@imm.ac.cn; yxcheng@mail.kib.ac.cn
推荐引用方式
GB/T 7714
Tang,Jian-Jun,Fang,Ping,Xia,Hou-Lin,et al. Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity[J]. FOOD RESEARCH INTERNATIONAL,2015,67:163-168.
APA Tang,Jian-Jun.,Fang,Ping.,Xia,Hou-Lin.,Tu,Zheng-Chao.,Hou,Bi-Yu.,...&yxcheng@mail.kib.ac.cn.(2015).Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity.FOOD RESEARCH INTERNATIONAL,67,163-168.
MLA Tang,Jian-Jun,et al."Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity".FOOD RESEARCH INTERNATIONAL 67(2015):163-168.
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