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题名: Antiviral isocoumarins from the roots and stems of Nicotiana tabacum
作者: Shang, Shan-Zhai1, 2; Xu, Wen-Xiu1, 3, 4; Li, Lan1, 3, 4; Tang, Jian-Guo1; Zhao, Wei1; Lei, Ping1; Miao, Ming-Ming1; null(孙汉董)2; Pu, Jian-Xin2; Chen, Yong-Kuan1; Yang, Guang-Yu1
刊名: PHYTOCHEMISTRY LETTERS
出版日期: 2015-03-01
卷号: 11, 页码:53-56
关键词: Nicotiana tabacum ; Isocoumarin derivatives ; Tabaisocoumarins A-C ; Anti-tobacco mosaic virus activity
学科分类: Biochemistry & Molecular Biology; Plant Sciences
DOI: 10.1016/j.phytol.2014.11.008
通讯作者: Chen,YK (reprint author),China Tobacco Yunnan Ind Co Ltd,Key Lab Tobacco Chem Yunnan Prov,Kunming 650231,Peoples R China. ; cyk1966@163.com ; ygy1110@163.com
文章类型: Article
英文摘要: Three new isocoumarin derivatives, tabaisocoumarins A-C (1-3), together with three known phenolic compounds (4-6), were isolated from the roots and stems of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 mu M. Compound 2 exhibited anti-TMV activity with inhibition rate of 33.8%, which is higher than that of positive control, ningnanmycin. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 18.7-28.5%, respectively. (C) 2014 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: MOSAIC-VIRUS ACTIVITIES ; PHENOLIC-COMPOUNDS ; CYTOTOXICITY ; DERIVATIVES ; TOBACCO ; LEAVES
收录类别: SCI
项目资助者: National Natural Science Foundation of China [31360081] ; Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd [2012JC01]
语种: 英语
WOS记录号: WOS:000350569100011
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20602
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.China Tobacco Yunnan Ind Co Ltd, Key Lab Tobacco Chem Yunnan Prov, Kunming 650231, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
3.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
4.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
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