New clerodane diterpenoids from the twigs and leaves of Croton euryphyllus
Pan, Zhenghong1; Ning, Desheng1; Wu, Xingde2; Huang, Sisi1; Li, Dianpeng1; Lv, Shihong1; Pan,ZH (reprint author),Chinese Acad Sci,Guangxi Inst Bot,Guangxi Key Lab Funct Phytochem Res & Utilizat,Guilin 541006,Peoples R China.; pan7260@126.com
2015-03-15
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号25期号:6页码:1329-1332
摘要Three new nor-clerodane diterpenoids, crotoeurins A-C (1-3), together with four known ones were isolated from the twigs and leaves of Croton euryphyllus. Among them, crotoeurin A (1) is a new nor-clerodane diterpenoid dimer with a unique cyclobutane ring via a [2+2] cycloaddition. Their structures were elucidated by spectroscopic analyses and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Compounds 1-3 exhibited neurite outgrowth-promoting activity on NGF-mediated PC12 cells at concentration of 10 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Croton Euryphyllus Crotoeurins A-c Nor-clerodane Diterpenoid Neurite Outgrowth-promoting Activity
资助信息National Natural Science Foundation of China [21102023]; West Light Foundation of the Chinese Academy of Sciences; Natural Science Foundation of Guangxi [2011GXNSFB018022]; Foundation of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization [ZRJJ2014-8]
学科领域Chemistry, Medicinal ; Chemistry, Organic
DOI10.1016/j.bmcl.2015.01.033
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000350696000032
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20601
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Pan,ZH (reprint author),Chinese Acad Sci,Guangxi Inst Bot,Guangxi Key Lab Funct Phytochem Res & Utilizat,Guilin 541006,Peoples R China.; pan7260@126.com
作者单位1.Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
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Pan, Zhenghong,Ning, Desheng,Wu, Xingde,et al. New clerodane diterpenoids from the twigs and leaves of Croton euryphyllus[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(6):1329-1332.
APA Pan, Zhenghong.,Ning, Desheng.,Wu, Xingde.,Huang, Sisi.,Li, Dianpeng.,...&pan7260@126.com.(2015).New clerodane diterpenoids from the twigs and leaves of Croton euryphyllus.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(6),1329-1332.
MLA Pan, Zhenghong,et al."New clerodane diterpenoids from the twigs and leaves of Croton euryphyllus".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.6(2015):1329-1332.
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