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题名: New clerodane diterpenoids from the twigs and leaves of Croton euryphyllus
作者: Pan, Zhenghong1; Ning, Desheng1; Wu, Xingde2; Huang, Sisi1; Li, Dianpeng1; Lv, Shihong1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期: 2015-03-15
卷号: 25, 期号:6, 页码:1329-1332
关键词: Croton euryphyllus ; Crotoeurins A-C ; Nor-clerodane diterpenoid ; Neurite outgrowth-promoting activity
学科分类: Chemistry, Medicinal; Chemistry, Organic
DOI: 10.1016/j.bmcl.2015.01.033
通讯作者: Pan,ZH (reprint author),Chinese Acad Sci,Guangxi Inst Bot,Guangxi Key Lab Funct Phytochem Res & Utilizat,Guilin 541006,Peoples R China. ; pan7260@126.com
文章类型: Article
英文摘要: Three new nor-clerodane diterpenoids, crotoeurins A-C (1-3), together with four known ones were isolated from the twigs and leaves of Croton euryphyllus. Among them, crotoeurin A (1) is a new nor-clerodane diterpenoid dimer with a unique cyclobutane ring via a [2+2] cycloaddition. Their structures were elucidated by spectroscopic analyses and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Compounds 1-3 exhibited neurite outgrowth-promoting activity on NGF-mediated PC12 cells at concentration of 10 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: NGF-POTENTIATING ACTIVITY ; NEOCLERODANE DITERPENOIDS
收录类别: SCI
项目资助者: National Natural Science Foundation of China [21102023] ; West Light Foundation of the Chinese Academy of Sciences ; Natural Science Foundation of Guangxi [2011GXNSFB018022] ; Foundation of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization [ZRJJ2014-8]
语种: 英语
WOS记录号: WOS:000350696000032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20601
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
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