New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis
Nian, Yin1; Yang, Jing1; Liu, Tong-Yang2; Luo, Ying2; Zhang, Ji-Hong2; Qiu, Ming-Hua1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhjihong2000@126.com; mhchiu@mail.kib.ac.cn
2015-03-12
Source PublicationSCIENTIFIC REPORTS
Volume5Pages:9026
AbstractCimyunnins A-C (1- 3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged c-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.
Subject AreaMultidisciplinary Sciences
DOI10.1038/srep09026
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000351144900003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20598
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhjihong2000@126.com; mhchiu@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China
Recommended Citation
GB/T 7714
Nian, Yin,Yang, Jing,Liu, Tong-Yang,et al. New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis[J]. SCIENTIFIC REPORTS,2015,5:9026.
APA Nian, Yin.,Yang, Jing.,Liu, Tong-Yang.,Luo, Ying.,Zhang, Ji-Hong.,...&mhchiu@mail.kib.ac.cn.(2015).New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis.SCIENTIFIC REPORTS,5,9026.
MLA Nian, Yin,et al."New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis".SCIENTIFIC REPORTS 5(2015):9026.
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