| New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis | |
Nian, Yin1 ; Yang, Jing1; Liu, Tong-Yang2; Luo, Ying2; Zhang, Ji-Hong2; Qiu, Ming-Hua1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhjihong2000@126.com; mhchiu@mail.kib.ac.cn
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| 2015-03-12 | |
| 发表期刊 | SCIENTIFIC REPORTS
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| 卷号 | 5页码:9026 |
| 摘要 | Cimyunnins A-C (1- 3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged c-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies. |
| 学科领域 | Multidisciplinary Sciences |
| DOI | 10.1038/srep09026 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351144900003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/20598 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhjihong2000@126.com; mhchiu@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nian, Yin,Yang, Jing,Liu, Tong-Yang,et al. New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis[J]. SCIENTIFIC REPORTS,2015,5:9026. |
| APA | Nian, Yin.,Yang, Jing.,Liu, Tong-Yang.,Luo, Ying.,Zhang, Ji-Hong.,...&mhchiu@mail.kib.ac.cn.(2015).New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis.SCIENTIFIC REPORTS,5,9026. |
| MLA | Nian, Yin,et al."New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis".SCIENTIFIC REPORTS 5(2015):9026. |
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