New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis
Nian, Yin1; Yang, Jing1; Liu, Tong-Yang2; Luo, Ying2; Zhang, Ji-Hong2; Qiu, Ming-Hua1; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhjihong2000@126.com; mhchiu@mail.kib.ac.cn
2015-03-12
发表期刊SCIENTIFIC REPORTS
卷号5页码:9026
摘要Cimyunnins A-C (1- 3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged c-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.
资助信息National Natural Science Foundation of China [U1132604, 81302670]; China Postdoctoral Science Foundation [2013M531996]
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20598
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhjihong2000@126.com; mhchiu@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China
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Nian, Yin,Yang, Jing,Liu, Tong-Yang,et al. New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis[J]. SCIENTIFIC REPORTS,2015,5:9026.
APA Nian, Yin.,Yang, Jing.,Liu, Tong-Yang.,Luo, Ying.,Zhang, Ji-Hong.,...&mhchiu@mail.kib.ac.cn.(2015).New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis.SCIENTIFIC REPORTS,5,9026.
MLA Nian, Yin,et al."New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis".SCIENTIFIC REPORTS 5(2015):9026.
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