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题名: New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifuga yunnanensis
作者: Nian, Yin1; Yang, Jing1; Liu, Tong-Yang2; Luo, Ying2; Zhang, Ji-Hong2; null(邱明华)1
刊名: SCIENTIFIC REPORTS
出版日期: 2015-03-12
卷号: 5, 页码:9026
学科分类: Multidisciplinary Sciences
DOI: 10.1038/srep09026
通讯作者: Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; zhjihong2000@126.com ; mhchiu@mail.kib.ac.cn
文章类型: Article
英文摘要: Cimyunnins A-C (1- 3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged c-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CYCLOARTANE TRITERPENOIDS ; CIMIFUGA-FOETIDA ; CHEMICAL-SHIFTS ; AERIAL PARTS ; CANCER-CELLS ; RHIZOMES ; GLYCOSIDES ; IMPLEMENTATION ; CONSTITUENTS ; PRINCIPLE
收录类别: SCI
项目资助者: National Natural Science Foundation of China [U1132604, 81302670] ; China Postdoctoral Science Foundation [2013M531996]
语种: 英语
WOS记录号: WOS:000351144900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20598
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Kunming Univ Sci & Technol, Fac Med, Lab Mol Genet Aging & Tumor, Kunming 650500, Peoples R China
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