Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.
The fruiting bodies of Ganoderma lucidum have been used in China for the prevention of a wide range of diseases including diabetic nephropathy. Our current investigation with this mushroom led to the isolation of six new and two known phenolic meroterpenoids. The structures and absolute configurations at all stereogenic centers in these substances were assigned by using spectroscopic and computational methods. The new meroterpenoids, chizhines A-F (1-6), are isolated as racemic mixtures. Chiral HPLC was utilized to obtain the individual (-)- and (+)-antipodes of these substances. The renoprotective effects of the selected members of the series, were evaluated by using the ELISA technique and high-glucose-induced rat mesangial cells. The results show that the individual enantiomers of these substances significantly inhibit monocyte chemotactic protein 1 (MCP-1) and fibronectin production in a dose-dependent manner. (C) 2014 Elsevier Ltd. All rights reserved.
National Natural Science Foundation of China [21272241, 21172223, 31271579, 81322030]
; Young and Middle Aged Academic Leaders of Kunming
; Center of Cooperative Innovation for South China Medicine of Yunnan Province