Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum | |
Luo, Qi1,2; Wang, Xin-Long1; Di, Lei1; Yan, Yong-Ming1,2; Lu, Qing1; Yang, Xiao-Hua1; Hu, Dong-Bao1; Cheng, Yong-Xian1; Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; yxcheng@mail.kib.ac.cn | |
2015-02-04 | |
发表期刊 | TETRAHEDRON |
卷号 | 71期号:5页码:840-845 |
摘要 | The fruiting bodies of Ganoderma lucidum have been used in China for the prevention of a wide range of diseases including diabetic nephropathy. Our current investigation with this mushroom led to the isolation of six new and two known phenolic meroterpenoids. The structures and absolute configurations at all stereogenic centers in these substances were assigned by using spectroscopic and computational methods. The new meroterpenoids, chizhines A-F (1-6), are isolated as racemic mixtures. Chiral HPLC was utilized to obtain the individual (-)- and (+)-antipodes of these substances. The renoprotective effects of the selected members of the series, were evaluated by using the ELISA technique and high-glucose-induced rat mesangial cells. The results show that the individual enantiomers of these substances significantly inhibit monocyte chemotactic protein 1 (MCP-1) and fibronectin production in a dose-dependent manner. (C) 2014 Elsevier Ltd. All rights reserved. |
关键词 | Ganoderma Lucidum Meroterpenoids Renoprotective |
学科领域 | Chemistry, Organic |
DOI | 10.1016/j.tet.2014.12.052 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000349194000010 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/20595 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.; yxcheng@mail.kib.ac.cn |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Luo, Qi,Wang, Xin-Long,Di, Lei,et al. Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum[J]. TETRAHEDRON,2015,71(5):840-845. |
APA | Luo, Qi.,Wang, Xin-Long.,Di, Lei.,Yan, Yong-Ming.,Lu, Qing.,...&yxcheng@mail.kib.ac.cn.(2015).Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum.TETRAHEDRON,71(5),840-845. |
MLA | Luo, Qi,et al."Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum".TETRAHEDRON 71.5(2015):840-845. |
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