Cheng,YX (reprint author),Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.
Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-beta 1-induced human renal proximal tubular cells.
NSFC-Joint Foundation of Yunnan Province [U1202222]
; National Natural Science Foundation of China 
; Center of Cooperative Innovation for South China Medicine of Yunnan Province
; Yong and Middle Aged Academic Leaders of Kunming
1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China