Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity
Luo, Qi1,3; Di, Lei1; Dai, Wei-Feng1,4; Lu, Qing1; Yan, Yong-Ming1,3; Yang, Zhu-Liang2; Li, Rong-Tao4; Cheng, Yong-Xian1; Cheng,YX (reprint author),Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.kib.ac.cn
2015-03-06
发表期刊ORGANIC LETTERS
卷号17期号:5页码:1110-1113
摘要Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-beta 1-induced human renal proximal tubular cells.
资助信息NSFC-Joint Foundation of Yunnan Province [U1202222]; National Natural Science Foundation of China [21472199]; Center of Cooperative Innovation for South China Medicine of Yunnan Province; Yong and Middle Aged Academic Leaders of Kunming
学科领域Chemistry, Organic
DOI10.1021/ol503610b
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000350841300013
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20594
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Cheng,YX (reprint author),Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.kib.ac.cn
作者单位1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
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Luo, Qi,Di, Lei,Dai, Wei-Feng,et al. Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity[J]. ORGANIC LETTERS,2015,17(5):1110-1113.
APA Luo, Qi.,Di, Lei.,Dai, Wei-Feng.,Lu, Qing.,Yan, Yong-Ming.,...&yxcheng@mail.kib.ac.cn.(2015).Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity.ORGANIC LETTERS,17(5),1110-1113.
MLA Luo, Qi,et al."Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity".ORGANIC LETTERS 17.5(2015):1110-1113.
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