| Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity | |
Luo, Qi1,3 ; Di, Lei1; Dai, Wei-Feng1,4; Lu, Qing1; Yan, Yong-Ming1,3; Yang, Zhu-Liang2; Li, Rong-Tao4; Cheng, Yong-Xian1; Cheng,YX (reprint author),Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.kib.ac.cn
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| 2015-03-06 | |
| 发表期刊 | ORGANIC LETTERS
 |
| 卷号 | 17期号:5页码:1110-1113 |
| 摘要 | Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-beta 1-induced human renal proximal tubular cells. |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/ol503610b |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350841300013 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/20594 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng,YX (reprint author),Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.kib.ac.cn |
| 作者单位 | 1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Qi,Di, Lei,Dai, Wei-Feng,et al. Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity[J]. ORGANIC LETTERS,2015,17(5):1110-1113. |
| APA | Luo, Qi.,Di, Lei.,Dai, Wei-Feng.,Lu, Qing.,Yan, Yong-Ming.,...&yxcheng@mail.kib.ac.cn.(2015).Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity.ORGANIC LETTERS,17(5),1110-1113. |
| MLA | Luo, Qi,et al."Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum That Displays Potent Antifibrotic Activity".ORGANIC LETTERS 17.5(2015):1110-1113. |
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