(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis
Luo, Qi1,3; Tian, Lei1,2; Di, Lei1; Yan, Yong-Ming1,3; Wei, Xiao-Yi4; Wang, Xin-Fang1; Cheng, Yong-Xian1,2; Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.Kib.ac.cn
2015-03-20
Source PublicationORGANIC LETTERS
Volume17Issue:6Pages:1565-1568
Abstract(+)- and (-)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures of these substances and absolute configurations at their stereocenters were assigned using spectroscopic and computational methods along with X-ray crystallographic analysis. A plausible pathway for the biosynthesis of 1 is proposed. (-)-1 was found to be a Smad3 phosphorylation inhibitor in TGF-beta 1 induced human renal proximal tubular cells.
Subject AreaChemistry, Organic
DOI10.1021/acs.orglett.5b00448
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000351558100055
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20593
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorCheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.Kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Henan Coll Tradit Chinese Med, Zhengzhou 450008, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Luo, Qi,Tian, Lei,Di, Lei,et al. (+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis[J]. ORGANIC LETTERS,2015,17(6):1565-1568.
APA Luo, Qi.,Tian, Lei.,Di, Lei.,Yan, Yong-Ming.,Wei, Xiao-Yi.,...&yxcheng@mail.Kib.ac.cn.(2015).(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis.ORGANIC LETTERS,17(6),1565-1568.
MLA Luo, Qi,et al."(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis".ORGANIC LETTERS 17.6(2015):1565-1568.
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