| (+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis | |
Luo, Qi1,3 ; Tian, Lei1,2; Di, Lei1; Yan, Yong-Ming1,3; Wei, Xiao-Yi4; Wang, Xin-Fang1; Cheng, Yong-Xian1,2; Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.Kib.ac.cn
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| 2015-03-20 | |
| 发表期刊 | ORGANIC LETTERS
 |
| 卷号 | 17期号:6页码:1565-1568 |
| 摘要 | (+)- and (-)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures of these substances and absolute configurations at their stereocenters were assigned using spectroscopic and computational methods along with X-ray crystallographic analysis. A plausible pathway for the biosynthesis of 1 is proposed. (-)-1 was found to be a Smad3 phosphorylation inhibitor in TGF-beta 1 induced human renal proximal tubular cells. |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/acs.orglett.5b00448 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351558100055 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/20593 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.Kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Henan Coll Tradit Chinese Med, Zhengzhou 450008, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Qi,Tian, Lei,Di, Lei,et al. (+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis[J]. ORGANIC LETTERS,2015,17(6):1565-1568. |
| APA | Luo, Qi.,Tian, Lei.,Di, Lei.,Yan, Yong-Ming.,Wei, Xiao-Yi.,...&yxcheng@mail.Kib.ac.cn.(2015).(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis.ORGANIC LETTERS,17(6),1565-1568. |
| MLA | Luo, Qi,et al."(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis".ORGANIC LETTERS 17.6(2015):1565-1568. |
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