(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis
Luo, Qi1,3; Tian, Lei1,2; Di, Lei1; Yan, Yong-Ming1,3; Wei, Xiao-Yi4; Wang, Xin-Fang1; Cheng, Yong-Xian1,2; Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.Kib.ac.cn
2015-03-20
发表期刊ORGANIC LETTERS
卷号17期号:6页码:1565-1568
摘要(+)- and (-)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures of these substances and absolute configurations at their stereocenters were assigned using spectroscopic and computational methods along with X-ray crystallographic analysis. A plausible pathway for the biosynthesis of 1 is proposed. (-)-1 was found to be a Smad3 phosphorylation inhibitor in TGF-beta 1 induced human renal proximal tubular cells.
资助信息NSFC-Joint Foundation of Yunnan Province [U1202222]; National Natural Science Foundation of China [21472199]; Research Fund of "South Drug" Research Collaborative Innovation Organization; distinguished professorship from Henan Province; Young and Middle Aged Academic Leaders of Kunming
学科领域Chemistry, Organic
DOI10.1021/acs.orglett.5b00448
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000351558100055
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20593
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; yxcheng@mail.Kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Henan Coll Tradit Chinese Med, Zhengzhou 450008, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
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GB/T 7714
Luo, Qi,Tian, Lei,Di, Lei,et al. (+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis[J]. ORGANIC LETTERS,2015,17(6):1565-1568.
APA Luo, Qi.,Tian, Lei.,Di, Lei.,Yan, Yong-Ming.,Wei, Xiao-Yi.,...&yxcheng@mail.Kib.ac.cn.(2015).(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis.ORGANIC LETTERS,17(6),1565-1568.
MLA Luo, Qi,et al."(+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis".ORGANIC LETTERS 17.6(2015):1565-1568.
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