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题名: (+/-)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis
作者: Luo, Qi1, 3; Tian, Lei1, 2; Di, Lei1; Yan, Yong-Ming1, 3; Wei, Xiao-Yi4; Wang, Xin-Fang1; null(程永现)1, 2
刊名: ORGANIC LETTERS
出版日期: 2015-03-20
卷号: 17, 期号:6, 页码:1565-1568
学科分类: Chemistry, Organic
DOI: 10.1021/acs.orglett.5b00448
通讯作者: Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; yxcheng@mail.Kib.ac.cn
文章类型: Article
英文摘要: (+)- and (-)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures of these substances and absolute configurations at their stereocenters were assigned using spectroscopic and computational methods along with X-ray crystallographic analysis. A plausible pathway for the biosynthesis of 1 is proposed. (-)-1 was found to be a Smad3 phosphorylation inhibitor in TGF-beta 1 induced human renal proximal tubular cells.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: POLYCYCLIC MEROTERPENOIDS ; COCHLEAR ; HYDROQUINONE ; EXPRESSION ; LUCIDUM ; POTENT
收录类别: SCI
项目资助者: NSFC-Joint Foundation of Yunnan Province [U1202222] ; National Natural Science Foundation of China [21472199] ; Research Fund of "South Drug" Research Collaborative Innovation Organization ; distinguished professorship from Henan Province ; Young and Middle Aged Academic Leaders of Kunming
语种: 英语
WOS记录号: WOS:000351558100055
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20593
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Henan Coll Tradit Chinese Med, Zhengzhou 450008, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
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