Cheng,YX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.
(+)- and (-)-Sinensilactam A (1), novel hybrid metabolites possessing a unique 2H-pyrrolo[2,1-b][1,3]oxazin-6(7H)-one ring system, were isolated from the fruit bodies of Ganoderma sinensis. The structures of these substances and absolute configurations at their stereocenters were assigned using spectroscopic and computational methods along with X-ray crystallographic analysis. A plausible pathway for the biosynthesis of 1 is proposed. (-)-1 was found to be a Smad3 phosphorylation inhibitor in TGF-beta 1 induced human renal proximal tubular cells.
NSFC-Joint Foundation of Yunnan Province [U1202222]
; National Natural Science Foundation of China 
; Research Fund of "South Drug" Research Collaborative Innovation Organization
; distinguished professorship from Henan Province
; Young and Middle Aged Academic Leaders of Kunming
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Henan Coll Tradit Chinese Med, Zhengzhou 450008, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.South China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China