Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors

doi:10.1016/j.bmcl.2015.02.009

	Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors
	Geng, Chang-An; Huang, Xiao-Yan; Ma, Yun-Bao; Zhang, Xue-Mei; Chen, Ji-Jun; Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; chenjj@mail.kib.ac.cn
	2015-04-01
发表期刊	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷号	25 期号:7 页码:1568-1571
摘要	Twenty-four derivatives of erythrocentaurin (ET) were synthesized and evaluated for their anti-HBV activities on HepG 2.2.15 cell line in vitro. Eight compounds 1, 2, 5, 8, 9, 1e, 1k, and 1m increased activity against HBV DNA replication with the SI values higher than 11. In particular, derivatives 1e and 1k exhibited the most potent inhibition on HBV DNA replication with the IC50 values of 0.026 mM (SI > 70.8) and 0.045 mM (SI > 36.0), respectively. The primary structure-activity relationships (SARs) of ET derivatives were summarized for exploring potent anti-HBV agents. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	Erythrocentaurin Anti-hbv Activity Structure-activity Relationships
学科领域	Chemistry, Medicinal ; Chemistry, Organic
DOI	10.1016/j.bmcl.2015.02.009
收录类别	SCI
语种	英语
WOS记录号	WOS:000351688700040
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/20583
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; chenjj@mail.kib.ac.cn
作者单位	Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Geng, Chang-An,Huang, Xiao-Yan,Ma, Yun-Bao,et al. Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(7):1568-1571.
APA	Geng, Chang-An.,Huang, Xiao-Yan.,Ma, Yun-Bao.,Zhang, Xue-Mei.,Chen, Ji-Jun.,...&chenjj@mail.kib.ac.cn.(2015).Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(7),1568-1571.
MLA	Geng, Chang-An,et al."Synthesis of erythrocentaurin derivatives as a new class of hepatitis B virus inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.7(2015):1568-1571.

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