Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.
Twenty-four derivatives of erythrocentaurin (ET) were synthesized and evaluated for their anti-HBV activities on HepG 2.2.15 cell line in vitro. Eight compounds 1, 2, 5, 8, 9, 1e, 1k, and 1m increased activity against HBV DNA replication with the SI values higher than 11. In particular, derivatives 1e and 1k exhibited the most potent inhibition on HBV DNA replication with the IC50 values of 0.026 mM (SI > 70.8) and 0.045 mM (SI > 36.0), respectively. The primary structure-activity relationships (SARs) of ET derivatives were summarized for exploring potent anti-HBV agents. (C) 2015 Elsevier Ltd. All rights reserved.
West Light Foundation of the Chinese Academy of Sciences
; National Science Foundation of China 
; International Foundation for Science in Sweden [F/5202-1]
; National Natural Science Foundation of China 
; Youth Innovation Promotion Association, CAS