Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1-7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.
National Key Basic Research Program of China (973)'s Project [2011CB915503]
; National High Technology Research and Development Program (863 Program) [2012AA092104]
; National Natural Science Foundation of China [31270402, 20902094, 41176148, 21002110]
; Strategic Leading Science and Technology Project of Chinese Academy of Sciences [XDA11030403]
; Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001]