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Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy
Li,Dongyan; Xue,Yongbo; Zhu,Hucheng; Li,Yan; Sun,Bin; Liu,Junjun; Yao,Guangmin; Zhang,Jinwen; Du,Guang; Zhang,Yonghui; Zhang,YH (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.
2015
Source PublicationRSC ADVANCES
Volume5Issue:7Pages:5277-5287
AbstractNine new polyprenylated acylphloroglucinols (PPAPs), hyperattenins A-I (1-9), together with thirteen known analogues (10-22), were isolated from the aerial parts of Hypericum attenuatum Choisy. The structures of 1-9 were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by a single X-ray crystallographic analysis, and the absolute configurations of 2-9 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 was characterised as a bicyclo[3.3.1] nonane derivative containing an unusual hemiacetal functionality formed by a series of redox reactions on its side chains, which occurs rarely in nature. All new isolates were evaluated for cytotoxic activities against several human cancer cell lines. Compound 9 exhibited significant inhibitory activity against the HL-60 and A-549 cell lines, with IC50 values of 2.04 and 3.26 mu M, respectively. Compound 9 also showed low toxicity to Beas-2B cells (IC50 = 14.36 mu M), suggesting that it could be a selective anti-tumour agent for leukaemia and lung cancer. Compounds 2-8 were also screened for their anti-HIV-1 activities.
Subject AreaChemistry, Multidisciplinary
DOI10.1039/c4ra11675e
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS IDWOS:000346733500077
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20563
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorZhang,YH (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.
Recommended Citation
GB/T 7714
Li,Dongyan,Xue,Yongbo,Zhu,Hucheng,et al. Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy[J]. RSC ADVANCES,2015,5(7):5277-5287.
APA Li,Dongyan.,Xue,Yongbo.,Zhu,Hucheng.,Li,Yan.,Sun,Bin.,...&Zhang,YH .(2015).Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy.RSC ADVANCES,5(7),5277-5287.
MLA Li,Dongyan,et al."Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy".RSC ADVANCES 5.7(2015):5277-5287.
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