| Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy | |
Li,Dongyan; Xue,Yongbo; Zhu,Hucheng; Li,Yan ; Sun,Bin; Liu,Junjun; Yao,Guangmin; Zhang,Jinwen; Du,Guang; Zhang,Yonghui; Zhang,YH (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China.
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| 2015 | |
| 发表期刊 | RSC ADVANCES
 |
| 卷号 | 5期号:7页码:5277-5287 |
| 摘要 | Nine new polyprenylated acylphloroglucinols (PPAPs), hyperattenins A-I (1-9), together with thirteen known analogues (10-22), were isolated from the aerial parts of Hypericum attenuatum Choisy. The structures of 1-9 were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by a single X-ray crystallographic analysis, and the absolute configurations of 2-9 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 was characterised as a bicyclo[3.3.1] nonane derivative containing an unusual hemiacetal functionality formed by a series of redox reactions on its side chains, which occurs rarely in nature. All new isolates were evaluated for cytotoxic activities against several human cancer cell lines. Compound 9 exhibited significant inhibitory activity against the HL-60 and A-549 cell lines, with IC50 values of 2.04 and 3.26 mu M, respectively. Compound 9 also showed low toxicity to Beas-2B cells (IC50 = 14.36 mu M), suggesting that it could be a selective anti-tumour agent for leukaemia and lung cancer. Compounds 2-8 were also screened for their anti-HIV-1 activities. |
| 学科领域 | Chemistry, Multidisciplinary |
| DOI | 10.1039/c4ra11675e |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346733500077 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/20563 |
| 专题 | 资源植物与生物技术所级重点实验室 |
| 通讯作者 | Zhang,YH (reprint author),Huazhong Univ Sci & Technol,Sch Pharm,Tongji Med Coll,Hubei Key Lab Nat Med Chem & Resource Evaluat,Wuhan 430030,Peoples R China. |
| 推荐引用方式 GB/T 7714 | Li,Dongyan,Xue,Yongbo,Zhu,Hucheng,et al. Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy[J]. RSC ADVANCES,2015,5(7):5277-5287. |
| APA | Li,Dongyan.,Xue,Yongbo.,Zhu,Hucheng.,Li,Yan.,Sun,Bin.,...&Zhang,YH .(2015).Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy.RSC ADVANCES,5(7),5277-5287. |
| MLA | Li,Dongyan,et al."Hyperattenins A-I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy".RSC ADVANCES 5.7(2015):5277-5287. |
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| li2014.pdf（1001KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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