Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense

doi:10.1055/s-0031-1280441

	Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense
	Liu, Jie-Qing; Wang, Cui-Fang; Li, Yan; Luo, Huai-Rong; Qiu, Ming-Hua
	2012-03-01
发表期刊	PLANTA MEDICA
卷号	78 期号:4 页码:368-376
摘要	A new pentanorlanostane, ganosineniol A (1), eight new lanostane triterpenoids, ganosinoside A (2), ganoderic acid Jc (3), ganoderic acid Jd (4), ganodermatetraol (5), ganolucidic acid.a (6), ganolucidate F (7), ganoderiol J (8), and methyl lucidenate Ha (9), and a new sesquiterpenoid, ganosinensine (10), together with eleven known triterpenoids (11-21), were isolated from the fruiting bodies of the fungus Ganoderma sinense. Chemical structures were determined based on spectroscopic evidence, including 1D, 2D NMR, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc (3) displayed selective inhibitory activity against HL-60 cells (IC50 = 8.30 mu M), and ganoderiol E (11) exhibited selective cytotoxic activity against MCF-7 cells (IC50 = 6.35 mu M). Meanwhile, compounds 5, 7, and ganolucidic acids B and C (19, 20) showed induction ability of hPXR-mediated CYP3A4 expression.
关键词	Ganoderma Sinense Ganodermataceae Triterpenoids Sesquiterpene Cytotoxicity Cyp3a4 Induction
DOI	10.1055/s-0031-1280441
收录类别	SCI
语种	英语
WOS记录号	WOS:000301343700011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/20446
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	Chinese Acad Sci, State Key Lab Photochem & Plant Resources W Chin, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,et al. Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense[J]. PLANTA MEDICA,2012,78(4):368-376.
APA	Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,Luo, Huai-Rong,&Qiu, Ming-Hua.(2012).Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense.PLANTA MEDICA,78(4),368-376.
MLA	Liu, Jie-Qing,et al."Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense".PLANTA MEDICA 78.4(2012):368-376.

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