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题名: Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense
作者: Liu, Jie-Qing1; Wang, Cui-Fang1; null(李艳)1; Luo, Huai-Rong1; Qiu, Ming-Hua1
刊名: PLANTA MEDICA
出版日期: 2012-03-01
卷号: 78, 期号:4, 页码:368-376
关键词: Ganoderma sinense ; Ganodermataceae ; triterpenoids ; sesquiterpene ; cytotoxicity ; CYP3A4 induction
DOI: 10.1055/s-0031-1280441
文章类型: Article
英文摘要: A new pentanorlanostane, ganosineniol A (1), eight new lanostane triterpenoids, ganosinoside A (2), ganoderic acid Jc (3), ganoderic acid Jd (4), ganodermatetraol (5), ganolucidic acid.a (6), ganolucidate F (7), ganoderiol J (8), and methyl lucidenate Ha (9), and a new sesquiterpenoid, ganosinensine (10), together with eleven known triterpenoids (11-21), were isolated from the fruiting bodies of the fungus Ganoderma sinense. Chemical structures were determined based on spectroscopic evidence, including 1D, 2D NMR, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc (3) displayed selective inhibitory activity against HL-60 cells (IC50 = 8.30 mu M), and ganoderiol E (11) exhibited selective cytotoxic activity against MCF-7 cells (IC50 = 6.35 mu M). Meanwhile, compounds 5, 7, and ganolucidic acids B and C (19, 20) showed induction ability of hPXR-mediated CYP3A4 expression.
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: LUCIDUM FR KARST ; TUMOR-CELLS ; TRITERPENOIDS ; CONSTITUENTS ; ACID ; LANOSTANOIDS ; CYTOTOXICITY ; INHIBITION ; STEROIDS ; TSUGAE
收录类别: SCI
语种: 英语
WOS记录号: WOS:000301343700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20446
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Photochem & Plant Resources W Chin, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,et al. Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense[J]. PLANTA MEDICA,2012,78(4):368-376.
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