Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense
Liu, Jie-Qing; Wang, Cui-Fang; Li, Yan; Luo, Huai-Rong; Qiu, Ming-Hua
2012-03-01
发表期刊PLANTA MEDICA
卷号78期号:4页码:368-376
摘要A new pentanorlanostane, ganosineniol A (1), eight new lanostane triterpenoids, ganosinoside A (2), ganoderic acid Jc (3), ganoderic acid Jd (4), ganodermatetraol (5), ganolucidic acid.a (6), ganolucidate F (7), ganoderiol J (8), and methyl lucidenate Ha (9), and a new sesquiterpenoid, ganosinensine (10), together with eleven known triterpenoids (11-21), were isolated from the fruiting bodies of the fungus Ganoderma sinense. Chemical structures were determined based on spectroscopic evidence, including 1D, 2D NMR, and mass spectral data. Furthermore, all isolates were tested for cytotoxic activity and induction ability of hPXR-mediated CYP3A4 expression. Among them, ganoderic acid Jc (3) displayed selective inhibitory activity against HL-60 cells (IC50 = 8.30 mu M), and ganoderiol E (11) exhibited selective cytotoxic activity against MCF-7 cells (IC50 = 6.35 mu M). Meanwhile, compounds 5, 7, and ganolucidic acids B and C (19, 20) showed induction ability of hPXR-mediated CYP3A4 expression.
关键词Ganoderma Sinense Ganodermataceae Triterpenoids Sesquiterpene Cytotoxicity Cyp3a4 Induction
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20446
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位Chinese Acad Sci, State Key Lab Photochem & Plant Resources W Chin, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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GB/T 7714
Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,et al. Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense[J]. PLANTA MEDICA,2012,78(4):368-376.
APA Liu, Jie-Qing,Wang, Cui-Fang,Li, Yan,Luo, Huai-Rong,&Qiu, Ming-Hua.(2012).Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense.PLANTA MEDICA,78(4),368-376.
MLA Liu, Jie-Qing,et al."Isolation and Bioactivity Evaluation of Terpenoids from the Medicinal Fungus Ganoderma sinense".PLANTA MEDICA 78.4(2012):368-376.
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