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题名: Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens
作者: Liu, Xu1; Zhan, Rui2; Wang, Wei Guang2; Du, Xue2; null(李艳)2; Zhang, Peng1; Pu, Jian Xin2; Wu, Ji Zhou1; Sun, Han Dong2
刊名: ARCHIVES OF PHARMACAL RESEARCH
关键词: Jianshirubesins D-F ; 11,20-Epoxy-ent-kauranoids ; Isodon rubescens ; Cytotoxicity
英文摘要: Three rare and new 11,20-epoxy-ent-kaurane diterpenoids, named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data. Found in the MTT assay to evaluate the cytotoxicity of compounds 1, 2, and 4, only 1 could selectively inhibit certain cell lines from proliferating. In addition, a simple structure-activity relationship discussion might suggest a new bioactive moiety, different from the alpha,beta-unsaturated ketone group.
出版日期: 2012-12-01
卷号: 35, 期号:12, 页码:2147-2151
语种: 英语
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20443
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Tongji Sch Pharm, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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