Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens
Liu, Xu1; Zhan, Rui2; Wang, Wei Guang2; Du, Xue2; Li, Yan2; Zhang, Peng1; Pu, Jian Xin2; Wu, Ji Zhou1; Sun, Han Dong2
2012-12-01
发表期刊ARCHIVES OF PHARMACAL RESEARCH
卷号35期号:12页码:2147-2151
摘要Three rare and new 11,20-epoxy-ent-kaurane diterpenoids, named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data. Found in the MTT assay to evaluate the cytotoxicity of compounds 1, 2, and 4, only 1 could selectively inhibit certain cell lines from proliferating. In addition, a simple structure-activity relationship discussion might suggest a new bioactive moiety, different from the alpha,beta-unsaturated ketone group.
关键词Jianshirubesins D-f Isodon Rubescens 11 Cytotoxicity 20-epoxy-ent-kauranoids
DOI10.1007/s12272-012-1212-6
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000312772900012
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20443
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Tongji Sch Pharm, Wuhan 430030, Hubei, Peoples R China
2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
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Liu, Xu,Zhan, Rui,Wang, Wei Guang,et al. Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens[J]. ARCHIVES OF PHARMACAL RESEARCH,2012,35(12):2147-2151.
APA Liu, Xu.,Zhan, Rui.,Wang, Wei Guang.,Du, Xue.,Li, Yan.,...&Sun, Han Dong.(2012).Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens.ARCHIVES OF PHARMACAL RESEARCH,35(12),2147-2151.
MLA Liu, Xu,et al."Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens".ARCHIVES OF PHARMACAL RESEARCH 35.12(2012):2147-2151.
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