Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida

doi:10.1021/np3005425

	Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida
	Luo, Zengwei 1; Wang, Fuqian 1; Zhang, Jinwen 2; Li, Xingyao 3; Zhang, Mengke 1; Hao, Xincai 1; Xue, Yongbo 1; Li, Yan3 ; Horgen, F. David 4; Yao, Guangmin 1; Zhang, Yonghui 1
	2012-12-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
卷号	75 期号:12 页码:2113-2120
摘要	Seven new alkaloids, N-methylhemeanthidine chloride (1), N-methyl-5,6-dihydroplicane (5), O-methylnerinine (6), N-ethoxycarbonylethylcrinasiadine (7), N-ethoxy-carbonylpropylcrinasiadine (8), N-phenethylcrinasiadine (9), and N-isopentylcrinasiadine (10), together with eight known alkaloids, hemeanthamin (2), 3-epimacronine (3), (+)-tazettine (4), N-methylcrinasiadine (11), trisphaeridine (12), 5,6-dihydrobicolorine (13), lycorine (14), and nigragillin (15), were isolated from the whole plants of Zephyranthes candida. The structures of the new compounds were established by spectroscopic data interpretation, with single-crystal X-ray diffraction analysis performed on 1. The absolute configuration of 3-epimacronine (3) was determined by single-crystal X-ray diffraction analysis with Cu K alpha irradiation. Compounds 1-15 were evaluated for their in vitro cytotoxicity against five human cancer cell lines and the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compounds 1, 2, 9, and 14 exhibited cytotoxicity with IC50 values ranging from 0.81 to 13 mu M with selectivity indices as high as 10 when compared to the Beas-2B cell line.
DOI	10.1021/np3005425
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000312823300011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/20440
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp Affiliated, Tongji Med Coll, Wuhan 430030, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 4.Hawaii Pacific Univ, Dept Nat Sci, Lab Marine Biol Chem, Kaneohe, HI 96744 USA
推荐引用方式 GB/T 7714	Luo, Zengwei,Wang, Fuqian,Zhang, Jinwen,et al. Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(12):2113-2120.
APA	Luo, Zengwei.,Wang, Fuqian.,Zhang, Jinwen.,Li, Xingyao.,Zhang, Mengke.,...&Zhang, Yonghui.(2012).Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida.JOURNAL OF NATURAL PRODUCTS,75(12),2113-2120.
MLA	Luo, Zengwei,et al."Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida".JOURNAL OF NATURAL PRODUCTS 75.12(2012):2113-2120.

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