Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida
Luo, Zengwei1; Wang, Fuqian1; Zhang, Jinwen2; Li, Xingyao3; Zhang, Mengke1; Hao, Xincai1; Xue, Yongbo1; Li, Yan3; Horgen, F. David4; Yao, Guangmin1; Zhang, Yonghui1
AbstractSeven new alkaloids, N-methylhemeanthidine chloride (1), N-methyl-5,6-dihydroplicane (5), O-methylnerinine (6), N-ethoxycarbonylethylcrinasiadine (7), N-ethoxy-carbonylpropylcrinasiadine (8), N-phenethylcrinasiadine (9), and N-isopentylcrinasiadine (10), together with eight known alkaloids, hemeanthamin (2), 3-epimacronine (3), (+)-tazettine (4), N-methylcrinasiadine (11), trisphaeridine (12), 5,6-dihydrobicolorine (13), lycorine (14), and nigragillin (15), were isolated from the whole plants of Zephyranthes candida. The structures of the new compounds were established by spectroscopic data interpretation, with single-crystal X-ray diffraction analysis performed on 1. The absolute configuration of 3-epimacronine (3) was determined by single-crystal X-ray diffraction analysis with Cu K alpha irradiation. Compounds 1-15 were evaluated for their in vitro cytotoxicity against five human cancer cell lines and the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compounds 1, 2, 9, and 14 exhibited cytotoxicity with IC50 values ranging from 0.81 to 13 mu M with selectivity indices as high as 10 when compared to the Beas-2B cell line.
Indexed BySCI ; IC
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000312823300011
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Document Type期刊论文
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Hosp Affiliated, Tongji Med Coll, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
4.Hawaii Pacific Univ, Dept Nat Sci, Lab Marine Biol Chem, Kaneohe, HI 96744 USA
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GB/T 7714
Luo, Zengwei,Wang, Fuqian,Zhang, Jinwen,et al. Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(12):2113-2120.
APA Luo, Zengwei.,Wang, Fuqian.,Zhang, Jinwen.,Li, Xingyao.,Zhang, Mengke.,...&Zhang, Yonghui.(2012).Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida.JOURNAL OF NATURAL PRODUCTS,75(12),2113-2120.
MLA Luo, Zengwei,et al."Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida".JOURNAL OF NATURAL PRODUCTS 75.12(2012):2113-2120.
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