Pestalotiopsis is a highly prolific genus with a plethora of diverse secondary metabolites. Pestalotiopsis sp. cr013 was isolated from aeciospores of Cronartium ribicola and subjected to phytochemical investigation based on its special environment. To understand the secondary metabolites of strain Pestalotiopsis sp. cr013, two new compounds 1 and 2 were isolated from solid fermentation products of the fungus. Two new structures were elucidated by extensive spectroscopic analyses, including 1D- and 2D-NMR, and HR-ESI-MS experiments. Compound 1 exhibited weak cytotoxicity activity against five cancer cell lines, with IC50 values of 18.99 mu M (HL-60), 17.68 mu M (SMMC-7721), 18.28 mu M (A-549), 21.67 mu M (MCF-7) and 12.27 mu M (SW480). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Southwest Forestry Univ, Life Sci Coll, Kunming 650224, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China