| Bioactive Isoquinoline Alkaloids from Corydalis saxicola | |
Huang, Qiao-Qin1,2; Bi, Jun-Long3; Sun, Qian-Yun4; Yang, Fu-Mei4; Wang, Yue-Hu1 ; Tang, Gui-Hua1; Zhao, Fu-Wei1; Wang, Huan1; Xu, Jin-Jin1; Kennelly, Edward J.5; Long, Chun-Lin1,5; Yin, Ge-Fen3
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| 2012 | |
| Source Publication | PLANTA MEDICA
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| Volume | 78Issue:1Pages:65-70 |
| Abstract | Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)2,-9- dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 mu M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity. |
| Keyword | Corydalis Saxicola Bunting Fumariaceae Isoquinoline Alkaloids Acetylcholinesterase |
| DOI | 10.1055/s-0031-1280126 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000299109700012 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/20394 |
| Collection | 资源植物与生物技术所级重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Heilongtan 650201, Kunming, Peoples R China 2.Yunnan Agr Univ, Coll Landscape & Hort, Kunming 650201, Peoples R China 3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China 4.Chinese Acad Sci, Guiyang, Peoples R China 5.Minzu Univ China, Coll Life & Environm Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Huang, Qiao-Qin,Bi, Jun-Long,Sun, Qian-Yun,et al. Bioactive Isoquinoline Alkaloids from Corydalis saxicola[J]. PLANTA MEDICA,2012,78(1):65-70. |
| APA | Huang, Qiao-Qin.,Bi, Jun-Long.,Sun, Qian-Yun.,Yang, Fu-Mei.,Wang, Yue-Hu.,...&Yin, Ge-Fen.(2012).Bioactive Isoquinoline Alkaloids from Corydalis saxicola.PLANTA MEDICA,78(1),65-70. |
| MLA | Huang, Qiao-Qin,et al."Bioactive Isoquinoline Alkaloids from Corydalis saxicola".PLANTA MEDICA 78.1(2012):65-70. |
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| s-0031-1280126.pdf（138KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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