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Bioactive Isoquinoline Alkaloids from Corydalis saxicola
Huang, Qiao-Qin1,2; Bi, Jun-Long3; Sun, Qian-Yun4; Yang, Fu-Mei4; Wang, Yue-Hu1; Tang, Gui-Hua1; Zhao, Fu-Wei1; Wang, Huan1; Xu, Jin-Jin1; Kennelly, Edward J.5; Long, Chun-Lin1,5; Yin, Ge-Fen3
Source PublicationPLANTA MEDICA
AbstractTwelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)2,-9- dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 mu M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.
KeywordCorydalis Saxicola Bunting Fumariaceae Isoquinoline Alkaloids Acetylcholinesterase
Indexed BySCI
WOS IDWOS:000299109700012
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Heilongtan 650201, Kunming, Peoples R China
2.Yunnan Agr Univ, Coll Landscape & Hort, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
4.Chinese Acad Sci, Guiyang, Peoples R China
5.Minzu Univ China, Coll Life & Environm Sci, Beijing, Peoples R China
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GB/T 7714
Huang, Qiao-Qin,Bi, Jun-Long,Sun, Qian-Yun,et al. Bioactive Isoquinoline Alkaloids from Corydalis saxicola[J]. PLANTA MEDICA,2012,78(1):65-70.
APA Huang, Qiao-Qin.,Bi, Jun-Long.,Sun, Qian-Yun.,Yang, Fu-Mei.,Wang, Yue-Hu.,...&Yin, Ge-Fen.(2012).Bioactive Isoquinoline Alkaloids from Corydalis saxicola.PLANTA MEDICA,78(1),65-70.
MLA Huang, Qiao-Qin,et al."Bioactive Isoquinoline Alkaloids from Corydalis saxicola".PLANTA MEDICA 78.1(2012):65-70.
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