Bioactive Isoquinoline Alkaloids from Corydalis saxicola
Huang, Qiao-Qin1,2; Bi, Jun-Long3; Sun, Qian-Yun4; Yang, Fu-Mei4; Wang, Yue-Hu1; Tang, Gui-Hua1; Zhao, Fu-Wei1; Wang, Huan1; Xu, Jin-Jin1; Kennelly, Edward J.5; Long, Chun-Lin1,5; Yin, Ge-Fen3
2012
发表期刊PLANTA MEDICA
卷号78期号:1页码:65-70
摘要Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)2,-9- dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 mu M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.
关键词Corydalis Saxicola Bunting Fumariaceae Isoquinoline Alkaloids Acetylcholinesterase
DOI10.1055/s-0031-1280126
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000299109700012
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20394
专题资源植物与生物技术所级重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Heilongtan 650201, Kunming, Peoples R China
2.Yunnan Agr Univ, Coll Landscape & Hort, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
4.Chinese Acad Sci, Guiyang, Peoples R China
5.Minzu Univ China, Coll Life & Environm Sci, Beijing, Peoples R China
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Huang, Qiao-Qin,Bi, Jun-Long,Sun, Qian-Yun,et al. Bioactive Isoquinoline Alkaloids from Corydalis saxicola[J]. PLANTA MEDICA,2012,78(1):65-70.
APA Huang, Qiao-Qin.,Bi, Jun-Long.,Sun, Qian-Yun.,Yang, Fu-Mei.,Wang, Yue-Hu.,...&Yin, Ge-Fen.(2012).Bioactive Isoquinoline Alkaloids from Corydalis saxicola.PLANTA MEDICA,78(1),65-70.
MLA Huang, Qiao-Qin,et al."Bioactive Isoquinoline Alkaloids from Corydalis saxicola".PLANTA MEDICA 78.1(2012):65-70.
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