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题名: Bioactive Isoquinoline Alkaloids from Corydalis saxicola
作者: Huang, Qiao-Qin1, 2; Bi, Jun-Long3; Sun, Qian-Yun4; Yang, Fu-Mei4; Wang, Yue-Hu1; Tang, Gui-Hua1; Zhao, Fu-Wei1; Wang, Huan1; Xu, Jin-Jin1; Kennelly, Edward J.5; Long, Chun-Lin1, 5; Yin, Ge-Fen3
刊名: PLANTA MEDICA
出版日期: 2012
卷号: 78, 期号:1, 页码:65-70
关键词: Corydalis saxicola Bunting ; Fumariaceae ; isoquinoline alkaloids ; acetylcholinesterase
DOI: 10.1055/s-0031-1280126
文章类型: Article
英文摘要: Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)2,-9- dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1a, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 mu M, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: MAGNETIC-RESONANCE SPECTROSCOPY ; C-13 NMR ASSIGNMENTS ; PROTOBERBERINE ALKALOIDS ; ABSOLUTE-CONFIGURATIONS ; TETRAZOLIUM SALT ; CONSTITUENTS ; INHIBITORS ; ASSAY ; H-1
收录类别: SCI
语种: 英语
WOS记录号: WOS:000299109700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20394
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Heilongtan 650201, Kunming, Peoples R China
2.Yunnan Agr Univ, Coll Landscape & Hort, Kunming 650201, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Peoples R China
4.Chinese Acad Sci, Guiyang, Peoples R China
5.Minzu Univ China, Coll Life & Environm Sci, Beijing, Peoples R China

Recommended Citation:
Huang, Qiao-Qin,Bi, Jun-Long,Sun, Qian-Yun,et al. Bioactive Isoquinoline Alkaloids from Corydalis saxicola[J]. PLANTA MEDICA,2012,78(1):65-70.
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