One new flavanoid and Anti-HIV active constituents from boussingaultia gracilis miers var. pseudobaselloides bailey
Qiong, Gu; Yun-Bao, Ma; Xue-Mei, Mang; Rui-Rui, Wang; Jun, Zhou; Yong-Tang, Meng; Ji-Jun, Chen
2007-08-10
发表期刊CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
卷号28期号:8页码:1508-1511
摘要Boussingaultia gracilis Miers var. pseudobaselloides Bailey (Basellaccae) is a folk medicine used as an analgesic and supplements, only a few research was reported on the chemical constituents of this plant. This paper presented its chemical and anti-HIV active constituents. By column chromatography (Silica and Sephadex LH-20 gel) methods, two flavanols and four flavones were isolated from the 70% (volume fraction) ethanol extract. Based on extensive spectral analysis (UV, IR, MS and 1D, 2D NMR), compounds 1-6 were identified as bougracol A (1), 4, 7-dihydroxy-5-methoxy-8-methyl-6-formyl-flavane (2), 7-O-methylunonal (3), 5,7-dihydroxy-6,8-dimethyl-2-phenyl-4H-1-benzopyran-4-one (4), desmosflavone (5) and demethoxymatteucinol (6). Among them, compound 1, a new flavan-diols, was deduced to be 7-hydroxy-5-methoxy-8-methyl-6-formyl-flavan-3 4-diols, and compounds 2-6 were. firstly obtained from this plant. Anti-HIV assay suggests that compounds 1, 2, 5, 6 showed weak anti-HIV activities with EC50 values of 45.09, 48.73, 55.47 and 82.75 mu mol/L, and TI values of 1.41, 1.20, 7.15 and >8.51, respectively.
关键词Boussingaultia Gracilis Miers Var. Pseudobaselloides Bailey Boussingol a Flavanoid Anti-hiv Activity
学科领域Chemistry ; Multidisciplinary
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000249048900024
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2019
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mechanisms, Lab Mol Immunopharm, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Qiong, Gu,Yun-Bao, Ma,Xue-Mei, Mang,et al. One new flavanoid and Anti-HIV active constituents from boussingaultia gracilis miers var. pseudobaselloides bailey[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(8):1508-1511.
APA Qiong, Gu.,Yun-Bao, Ma.,Xue-Mei, Mang.,Rui-Rui, Wang.,Jun, Zhou.,...&Ji-Jun, Chen.(2007).One new flavanoid and Anti-HIV active constituents from boussingaultia gracilis miers var. pseudobaselloides bailey.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,28(8),1508-1511.
MLA Qiong, Gu,et al."One new flavanoid and Anti-HIV active constituents from boussingaultia gracilis miers var. pseudobaselloides bailey".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 28.8(2007):1508-1511.
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