Four new compounds from the basidiomycete Craterellus odoratus
Guo, Hua1,2,3; Feng, Tao1; Li, Zheng-Hui1; Liu, Ji-Kai1
2012
发表期刊JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷号14期号:10页码:950-955
摘要Four new compounds, craterellin D (1), 5-hydroxymethyl-2-hydroxy-4-methoxy-phenylethanone (2), 5-carboxyl-2-[2-(1,2-dihydroxyisopropyl)]-benzofuran (3), and 6 alpha-hydroxy-3-methoxy-4 alpha-methyl-2-cyclohexen-1-one (4), were isolated from cultures of the basidiomycete Craterellus odoratus, together with three known compounds craterellins A-C (5-7). Structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis. Selected compounds were evaluated for their inhibitory activities against one isozyme of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) and cytotoxic activities on five tumor cell lines. Compound 2 was found to exhibit inhibitory activity against human 11 beta-HSD1 with an IC50 value of 16.4 mu g/ml.
关键词Craterellus Odoratus Craterellin d 5-hydroxymethyl-2-hydroxy-4-methoxy-phenylethanone 6 Alpha-hydroxy-3-methoxy-4 Alpha-methyl-2-cyclohexen-1-one 5-carboxyl-2-[2-(1 2-dihydroxyisopropyl)]-benzofuran
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20092
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Anshan Normal Coll, Sch Chem & Life Sci, Anshan 114005, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Guo, Hua,Feng, Tao,Li, Zheng-Hui,et al. Four new compounds from the basidiomycete Craterellus odoratus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2012,14(10):950-955.
APA Guo, Hua,Feng, Tao,Li, Zheng-Hui,&Liu, Ji-Kai.(2012).Four new compounds from the basidiomycete Craterellus odoratus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,14(10),950-955.
MLA Guo, Hua,et al."Four new compounds from the basidiomycete Craterellus odoratus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 14.10(2012):950-955.
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