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题名: Four new compounds from the basidiomycete Craterellus odoratus
作者: Guo, Hua1, 2, 3; Feng, Tao1; Li, Zheng-Hui1; Liu, Ji-Kai1
刊名: JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
关键词: Craterellus odoratus ; craterellin D ; 5-hydroxymethyl-2-hydroxy-4-methoxy-phenylethanone ; 5-carboxyl-2-[2-(1,2-dihydroxyisopropyl)]-benzofuran ; 6 alpha-hydroxy-3-methoxy-4 alpha-methyl-2-cyclohexen-1-one
英文摘要: Four new compounds, craterellin D (1), 5-hydroxymethyl-2-hydroxy-4-methoxy-phenylethanone (2), 5-carboxyl-2-[2-(1,2-dihydroxyisopropyl)]-benzofuran (3), and 6 alpha-hydroxy-3-methoxy-4 alpha-methyl-2-cyclohexen-1-one (4), were isolated from cultures of the basidiomycete Craterellus odoratus, together with three known compounds craterellins A-C (5-7). Structures of 1-4 were elucidated on the basis of extensive spectroscopic analysis. Selected compounds were evaluated for their inhibitory activities against one isozyme of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) and cytotoxic activities on five tumor cell lines. Compound 2 was found to exhibit inhibitory activity against human 11 beta-HSD1 with an IC50 value of 16.4 mu g/ml.
出版日期: 2012
卷号: 14, 期号:10, 页码:950-955
语种: 英语
收录类别: SCI ; IC
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20092
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Anshan Normal Coll, Sch Chem & Life Sci, Anshan 114005, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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