Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida
Cheng, Pi; Ma, Yun-bao; Yao, Shu-ying; Zhang, Quan; Wang, En-jun; Yan, Meng-hong; Zhang, Xue-mei; Zhang, Feng-xue; Chen, Ji-jun
2007-10-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号17期号:19页码:5316-5320
摘要Two new alkaloids, hypserpanines A and B (1, 11), together with eleven known compounds, phenolbetain (2), acutumine (3), acutumidine (4), dechloroacutumine (5), dauricumine (6), dauricumidine (7), pronuciferine (8), glaziovine (9), S-reticuline (10), magnoflorine (12) and laurifoline(13), were isolated from Hypserpa nitida Miers. (Menispermaccae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine (7), exhibited an IC50 value of 0.450 mM (SI = 4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line. (C) 2007 Elsevier Ltd. All rights reserved.
关键词Hipserpa Nitida Menispermaceac Hypserpanine a Hypserpanine b Structure Elucidation Anti-hbv Activity
收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/2009
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Yunnam, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Guangzhou Univ Traditat Chinese Med, Inst Trop Med Sci, Guangzhou, Peoples R China
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Cheng, Pi,Ma, Yun-bao,Yao, Shu-ying,et al. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(19):5316-5320.
APA Cheng, Pi.,Ma, Yun-bao.,Yao, Shu-ying.,Zhang, Quan.,Wang, En-jun.,...&Chen, Ji-jun.(2007).Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(19),5316-5320.
MLA Cheng, Pi,et al."Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.19(2007):5316-5320.
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