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题名: Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida
作者: Cheng, Pi; Ma, Yun-bao; Yao, Shu-ying; Zhang, Quan; Wang, En-jun; Yan, Meng-hong; Zhang, Xue-mei; Zhang, Feng-xue; null(陈纪军)
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: Hipserpa nitida ; menispermaceac ; hypserpanine A ; hypserpanine B ; structure elucidation ; anti-HBV activity
英文摘要: Two new alkaloids, hypserpanines A and B (1, 11), together with eleven known compounds, phenolbetain (2), acutumine (3), acutumidine (4), dechloroacutumine (5), dauricumine (6), dauricumidine (7), pronuciferine (8), glaziovine (9), S-reticuline (10), magnoflorine (12) and laurifoline(13), were isolated from Hypserpa nitida Miers. (Menispermaccae) and chemically elucidated through spectral analyses. All the isolated alkaloids were evaluated for their anti-HBV activities in vitro using the HBV transfected Hep G2.2.15 cell line. The most active compound, dauricumidine (7), exhibited an IC50 value of 0.450 mM (SI = 4.13) on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line. (C) 2007 Elsevier Ltd. All rights reserved.
出版日期: 2007-10-01
卷号: 17, 期号:19, 页码:5316-5320
DOI标识: 10.1016/j.bmcl.2007.08.027
语种: 英语
ISSN号: 0960-894X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/2009
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Branch, Joint Lab Antiviral Nat Med, Kunming 650204, Yunnam, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Guangzhou Univ Traditat Chinese Med, Inst Trop Med Sci, Guangzhou, Peoples R China

Recommended Citation:
Cheng, P; Ma, YB; Yao, SY; Zhang, Q; Wang, EJ; Yan, MH; Zhang, XM; Zhang, FX; Chen, JJ.Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(19):5316-5320
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