Sixteen known compounds isolated from the whole plants of Euphorbia tangutica, including phorbol-13-actate (1) previously synthesised and obtained from a natural source for the first time, were evaluated in vitro against a panel of human cancer cell lines using the MTT method. Among them, ergosterol (6) exhibited significant cytotoxic activity against HL-60 cell line with an IC50 value of 3.3 mu M, and 3 beta,5 alpha-dihydroxy-15 beta-cinnamoyloxy-14-oxolathyra-6Z,12 E-diene (7) also displayed moderate activity.
1.Chinese Acad Sci, NW Inst Plateau Biol, Xining 810008, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China 4.Peking Union Med Coll, Beijing 100193, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Zhang, Ben-Yin,Wang, Huan,Luo, Xiao-Dong,et al. Chemical constituents of Euphorbia tangutica[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2309-2315.