Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase

doi:10.1021/np0702077

	Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase
	Wang, Yue-Hu; Zhang, Zhong-Kai ; Yang, Fu-Mei ; Sun, Qian-Yun ; He, Hong-Ping ; Di, Ying-Tong; Mu, Shu-Zhen ; Lu, Yang ; Chang, Ying ; Zheng, Qi-Tai ; Ding, Ming ; Dong, Jia-Hong ; Hao, Xiao-Jiang
	2007-09-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	70 期号:9 页码:1458-1461
摘要	Five new benzylphenethylamine alkaloids, hostasine (1), 8-demethoxyhostasine, 8-demethoxy-10-O-methylhostasine, 10-O-methylhostasirie, and 9-O-demethyl-7-O-methyllycorenine, along with 12 known compounds, were isolated from Hosta plantaginea by bioassay-guided fractionation. The structures of the new alkaloids were established by means of extensive spectroscopic methods, and the relative configuration of I was further confirmed by single-crystal X-ray diffraction. 7-Deoxy-trans-dihydronarciclasine (IC50 = 1.80 mu M), a known alkaloid, showed strong activity against tobacco mosaic virus by the half-leaf method. Some of these alkaloids were also evaluated for their inhibitory activity against acetylcholinesterase. 8-Demethoxy-10-O-methylhostasine was found to possess significant activity, with an IC50 of 2.32 mu M.
关键词	Amaryllidaceae Alkaloids Cytostatic Activity Steroidal Saponins Hl-60 Cells Hymenocallis Ungeremine Plants Bulbs
学科领域	Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np0702077
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000249871200013
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2005
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Yunnan Acad Agr Sci, Yunnan Key Lab Agr Biotechnol, Kunming 650223, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China 5.Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China 6.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yue-Hu,Zhang, Zhong-Kai,Yang, Fu-Mei,et al. Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase[J]. JOURNAL OF NATURAL PRODUCTS,2007,70(9):1458-1461.
APA	Wang, Yue-Hu.,Zhang, Zhong-Kai.,Yang, Fu-Mei.,Sun, Qian-Yun.,He, Hong-Ping.,...&Hao, Xiao-Jiang.(2007).Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.JOURNAL OF NATURAL PRODUCTS,70(9),1458-1461.
MLA	Wang, Yue-Hu,et al."Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase".JOURNAL OF NATURAL PRODUCTS 70.9(2007):1458-1461.

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