Two new antibacterial sesquiterpenoids from Centipeda minima
Liang, Heng-Xing1,2; Bao, Fu-Kai3; Dong, Xiao-Ping2; Zhu, Hua-Jie1; Lu, Xiao-Jie1; Shi, Ming3; Lu, Qing1; Cheng, Yong-Xian1
AbstractTwo new guaiane-type sesquiterpene lactones, compounds I and 2, along with three known Guaianolide- or pseudoguaianolides, were isolated from Centipeda minima (whole plant). Their structures were identified by spectroscopic and mass-spectrometric analyses. The configuration at C(5) of the guaiane framework of I was rationalized by quantum-mechanical calculations (Table 2). All compounds were found to be active against eight different microbial pathogens (Table 3), with MIC values in the range of 6.25-100 mu g/ml.
KeywordNmr Chemical-shifts Biologically-active Constituents Antiallergy Activity Perturbation-theory Medicinal-plants C-13 Configuration Guaianolide Inhibitor Lactones
Subject AreaBiochemistry & Molecular Biology ; Chemistry ; Multidisciplinary
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000252235500012
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Peoples R China
3.Kunming Med Coll, Dept Microbiol & Immunol, Kunming 650031, Peoples R China
Recommended Citation
GB/T 7714
Liang, Heng-Xing,Bao, Fu-Kai,Dong, Xiao-Ping,et al. Two new antibacterial sesquiterpenoids from Centipeda minima[J]. CHEMISTRY & BIODIVERSITY,2007,4(12):2810-2816.
APA Liang, Heng-Xing.,Bao, Fu-Kai.,Dong, Xiao-Ping.,Zhu, Hua-Jie.,Lu, Xiao-Jie.,...&Cheng, Yong-Xian.(2007).Two new antibacterial sesquiterpenoids from Centipeda minima.CHEMISTRY & BIODIVERSITY,4(12),2810-2816.
MLA Liang, Heng-Xing,et al."Two new antibacterial sesquiterpenoids from Centipeda minima".CHEMISTRY & BIODIVERSITY 4.12(2007):2810-2816.
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