Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation
Lu, Qing1; Zhang, Li2; He, Guo-Rong2; Liang, Heng-Xing1; Du, Guan-Hua2; Cheng, Yong-Xian1
2007
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号4期号:12页码:2948-2952
摘要Two new alkaloids, brachystemidines F (1) and G (2), were isolated from the roots of Brachystemma calycinum. Their structures were established on the basis of detailed spectroscopic analyses, including extensive NMR and HR-MS techniques. Compound 2, which exhibits an unusual N-hydroxydiazenyl (HO-N=N) moiety, is a potent immunosuppressive agent, as demonstrated by inhibition of mouse T- and B-lymphocyte proliferation, with IC50 values of 6.33 and 5.60 mu g/ml, resp.
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1953
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Botany, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
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Lu, Qing,Zhang, Li,He, Guo-Rong,et al. Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation[J]. CHEMISTRY & BIODIVERSITY,2007,4(12):2948-2952.
APA Lu, Qing,Zhang, Li,He, Guo-Rong,Liang, Heng-Xing,Du, Guan-Hua,&Cheng, Yong-Xian.(2007).Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation.CHEMISTRY & BIODIVERSITY,4(12),2948-2952.
MLA Lu, Qing,et al."Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation".CHEMISTRY & BIODIVERSITY 4.12(2007):2948-2952.
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