One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M. kurzii for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-17 were tested for their cytotoxicity against A-549 and Hep G2 cancer cell lines and showed IC50 values in the range of 9.76-30.14 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.
National Natural Science Foundation of China [31300293, 81202584]
; General Project of Applied Foundation Research, Yunnan Province [2013FB067]
; Basic Research Project of Ministry of Science and Technology of China [2012FY110300]
; Major State Basic Research Development Program [2010CB951704]
1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Germplasm Bank Wild Species Southwest China, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650201, Peoples R China 4.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China