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题名: Cytotoxic prenylated bibenzyls and flavonoids from Macaranga kurzii
作者: Yang, Da-Song1, 2, 3; Wei, Jian-Guo1, 2, 3; Peng, Wei-Bing4; Wang, Shuang-Mei1, 2, 3; Sun, Chen4; Yang Yongping(杨永平)1, 2, 3; Liu, Ke-Chun4; Li, Xiao-Li1, 2, 3
刊名: FITOTERAPIA
出版日期: 2014-12-01
卷号: 99, 页码:261-266
关键词: Macaranga kurzii ; Euphorbiaceae ; Prenylated flavonoids ; Prenylated bibenzyls ; Cytotoxicity
学科分类: Chemistry, Medicinal; Pharmacology & Pharmacy
DOI: 10.1016/j.fitote.2014.10.003
通讯作者: Li,XL (reprint author),Chinese Acad Sci,Key Lab Econ Plants & Biotechnol,Kunming 650201,Peoples R China. ; li_xiaolill@mail.kib.ac.cn
文章类型: Article
英文摘要: One unique prenylated bibenzyl, kurzphenol A (1), two new prenylated flavonoids, kurzphenols B and C (2 and 3), as well as fourteen known compounds (4-17) were isolated from the twigs of Macaranga kurzii. Compound 1 was the first example of prenylated bibenzyl which possesses a benzofuran ring. All the known compounds were isolated from M. kurzii for the first time. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 1-17 were tested for their cytotoxicity against A-549 and Hep G2 cancer cell lines and showed IC50 values in the range of 9.76-30.14 mu g/mL. (C) 2014 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CONSTITUENTS ; DERIVATIVES ; LEAVES ; CHEMOSYSTEMATICS ; BRYOPHYTES ; COMPONENTS ; STILBENES ; PLANTS
收录类别: SCI
项目资助者: National Natural Science Foundation of China [31300293, 81202584] ; General Project of Applied Foundation Research, Yunnan Province [2013FB067] ; Basic Research Project of Ministry of Science and Technology of China [2012FY110300] ; Major State Basic Research Development Program [2010CB951704]
语种: 英语
WOS记录号: WOS:000347019000033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19378
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Germplasm Bank Wild Species Southwest China, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650201, Peoples R China
4.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China
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