Isolation and synthesis of two hydroxychavicol heterodimers from Piper nudibaccatum
Liu, Hong-Xin1,2,3,4; Tan, Hai-Bo3; He, Meng-Ting5; Li, Ling5; Wang, Yue-Hu1,2; Long, Chun-Lin1,2,6; Wang,YH (reprint author),Chinese Acad Sci,Key Lab Econ Plants & Biotechnol,Kunming Inst Bot,Kunming 650201,Peoples R China.; wan-gyuehu@mail.kib.ac.cn; long@mail.kib.ac.cn
2015-04-22
发表期刊TETRAHEDRON
卷号71期号:16页码:2369-2375
摘要Two hydroxychavicol heterodimers comprising phenylpropanoid and monoterpene constituent units, named nudibaccatumins A (1) and B (2), were isolated as an inseparable mixture from the aerial parts of Piper nudibaccatum. Their absolute configurations were confirmed by total synthesis using ortho-alkylation of hydroxychavicol with myrtenyl bromide as the key reaction. The two new compounds (1 and 2) and their synthetic analogues (3-8) were evaluated for XO inhibitory activity. (C) 2015 Elsevier Ltd. All rights reserved.
关键词Piper Nudibaccatum Ortho-alkylation Nudibaccatumin a Nudibaccatumin b
资助信息National Natural Science Foundation of China [31161140345, 31070288, 81360505]; Natural Science Foundation of Yunnan Province, China [2011FZ205, 2013FA017]; Ministry of Science & Technology of China [2012FY110300]; Ministry of Education of China through its 111 and 985 projects [B08044, MUC985]; ISPS Asian Core program [JSPS/AP/109080]
学科领域Chemistry, Organic
DOI10.1016/j.tet.2015.03.005
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000352668900005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19370
专题资源植物与生物技术所级重点实验室
通讯作者Wang,YH (reprint author),Chinese Acad Sci,Key Lab Econ Plants & Biotechnol,Kunming Inst Bot,Kunming 650201,Peoples R China.; wan-gyuehu@mail.kib.ac.cn; long@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China
6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Liu, Hong-Xin,Tan, Hai-Bo,He, Meng-Ting,et al. Isolation and synthesis of two hydroxychavicol heterodimers from Piper nudibaccatum[J]. TETRAHEDRON,2015,71(16):2369-2375.
APA Liu, Hong-Xin.,Tan, Hai-Bo.,He, Meng-Ting.,Li, Ling.,Wang, Yue-Hu.,...&long@mail.kib.ac.cn.(2015).Isolation and synthesis of two hydroxychavicol heterodimers from Piper nudibaccatum.TETRAHEDRON,71(16),2369-2375.
MLA Liu, Hong-Xin,et al."Isolation and synthesis of two hydroxychavicol heterodimers from Piper nudibaccatum".TETRAHEDRON 71.16(2015):2369-2375.
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