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题名: Isolation and synthesis of two hydroxychavicol heterodimers from Piper nudibaccatum
作者: Liu, Hong-Xin1, 2, 3, 4; Tan, Hai-Bo3; He, Meng-Ting5; Li, Ling5; Wang YueHu(王跃虎)1, 2; Long, Chun-Lin1, 2, 6
刊名: TETRAHEDRON
出版日期: 2015-04-22
卷号: 71, 期号:16, 页码:2369-2375
关键词: Piper nudibaccatum ; ortho-alkylation ; Nudibaccatumin A ; Nudibaccatumin B
学科分类: Chemistry, Organic
DOI: 10.1016/j.tet.2015.03.005
通讯作者: Wang,YH (reprint author),Chinese Acad Sci,Key Lab Econ Plants & Biotechnol,Kunming Inst Bot,Kunming 650201,Peoples R China. ; wan-gyuehu@mail.kib.ac.cn ; long@mail.kib.ac.cn
文章类型: Article
英文摘要: Two hydroxychavicol heterodimers comprising phenylpropanoid and monoterpene constituent units, named nudibaccatumins A (1) and B (2), were isolated as an inseparable mixture from the aerial parts of Piper nudibaccatum. Their absolute configurations were confirmed by total synthesis using ortho-alkylation of hydroxychavicol with myrtenyl bromide as the key reaction. The two new compounds (1 and 2) and their synthetic analogues (3-8) were evaluated for XO inhibitory activity. (C) 2015 Elsevier Ltd. All rights reserved.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: XANTHINE-OXIDASE ; PHYTOCHEMISTRY
收录类别: SCI
项目资助者: National Natural Science Foundation of China [31161140345, 31070288, 81360505] ; Natural Science Foundation of Yunnan Province, China [2011FZ205, 2013FA017] ; Ministry of Science & Technology of China [2012FY110300] ; Ministry of Education of China through its 111 and 985 projects [B08044, MUC985] ; ISPS Asian Core program [JSPS/AP/109080]
语种: 英语
WOS记录号: WOS:000352668900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19370
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, Kunming 650201, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China
6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
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