Two hydroxychavicol heterodimers comprising phenylpropanoid and monoterpene constituent units, named nudibaccatumins A (1) and B (2), were isolated as an inseparable mixture from the aerial parts of Piper nudibaccatum. Their absolute configurations were confirmed by total synthesis using ortho-alkylation of hydroxychavicol with myrtenyl bromide as the key reaction. The two new compounds (1 and 2) and their synthetic analogues (3-8) were evaluated for XO inhibitory activity. (C) 2015 Elsevier Ltd. All rights reserved.
National Natural Science Foundation of China [31161140345, 31070288, 81360505]
; Natural Science Foundation of Yunnan Province, China [2011FZ205, 2013FA017]
; Ministry of Science & Technology of China [2012FY110300]
; Ministry of Education of China through its 111 and 985 projects [B08044, MUC985]
; ISPS Asian Core program [JSPS/AP/109080]
1.Chinese Acad Sci, Key Lab Econ Plants & Biotechnol, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Yunnan Key Lab Wild Plant Resources, Kunming Inst Bot, Kunming 650201, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 5.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Peoples R China 6.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China