Identification of Compounds from the Water Soluble Extract of Cinnamomum cassia Barks and Their Inhibitory Effects against High-Glucose-Induced Mesangial Cells
Luo, Qi1,4; Wang, Shu-Mei3; Lu, Qing1; Luo, Jie1; Cheng, Yong-Xian1,2
2013-09-01
发表期刊MOLECULES
卷号18期号:9页码:10930-10943
摘要The difficulty of diabetic nephropathy (DN) treatment makes prevention the best choice. Cinnamomum cassia barks, known as Chinese cinnamon or Chinese cassia, is one of the most popular natural spices and flavoring agents in many parts of the World. Since previous reports indicated that Chinese cinnamon extract could be used for the treatment of diabetes, we proposed that this spice may be beneficial for the prevention of DN. However, the responsible compounds need to be further identified. In this study, we isolated three new phenolic glycosides, cinnacassosides A-C (1-3), together with fifteen known compounds from the water soluble extract of Chinese cinnamon. The structures of the new compounds were identified by comprehensive spectroscopic evidence. Eleven compounds (6-9, 11, 13-18) were isolated from this spice for the first time, despite extensive research on this species in the past, which added new facets for the chemical profiling of this spice. These isolates were purposely evaluated for their inhibitory effects on IL-6 and extracellular matrix production in mesangial cells which are definitely implicated in DN. The results showed that compounds 4-8 could inhibit over secretion of IL-6, collagen IV and fibronectin against high-glucose-induced mesangial cells at 10 mu M, suggesting that Chinese cinnamon could be used as a functional food against DN.
关键词Chinese Cinnamon Cinnamomum Cassia Lauraceae Phenolic Compounds Diabetic Nephropathy
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000330306600055
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19249
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610075, Sichuan, Peoples R China
3.Guangdong Pharmaceut Univ, Coll Chinese Med, Guangzhou 510006, Guangdong, Peoples R China
4.Dali Univ, Coll Pharmaceut Sci, Dali 671002, Yunnan, Peoples R China
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GB/T 7714
Luo, Qi,Wang, Shu-Mei,Lu, Qing,et al. Identification of Compounds from the Water Soluble Extract of Cinnamomum cassia Barks and Their Inhibitory Effects against High-Glucose-Induced Mesangial Cells[J]. MOLECULES,2013,18(9):10930-10943.
APA Luo, Qi,Wang, Shu-Mei,Lu, Qing,Luo, Jie,&Cheng, Yong-Xian.(2013).Identification of Compounds from the Water Soluble Extract of Cinnamomum cassia Barks and Their Inhibitory Effects against High-Glucose-Induced Mesangial Cells.MOLECULES,18(9),10930-10943.
MLA Luo, Qi,et al."Identification of Compounds from the Water Soluble Extract of Cinnamomum cassia Barks and Their Inhibitory Effects against High-Glucose-Induced Mesangial Cells".MOLECULES 18.9(2013):10930-10943.
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