Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens
Liu, Ya-Ping1; Zhao, Yun-Li1; Feng, Tao1; Cheng, Gui-Guang1,2; Zhang, Bao-Hong3; Li, Yan1; Cai, Xiang-Hai1; Luo, Xiao-Dong1
2013-12-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume76Issue:12Pages:2322-2329
AbstractEight new bisindole alkaloids, melosuavines A C (1-3), having an aspidosperma-scandine linkage, melosuavines D F (4-6), possessing an aspidosperma-aspidosperma skeleton, and melosuavines G and H (7 and 8) of the aspidosperma-venalatonine type, tenuicausine (9), and melodinine J (10) were isolated from the twigs and leaves of Melodinus suaveolens. The structures of 1-8 were elucidated by extensive spectroscopic methods, and compounds 9 and 10 were identified by comparison with data in the literature. The relative configuration 9 was determined from the ROESY spectrum, and some NMR signals were reassigned. Compounds 1, 2, 4-6, 8, and 10 exhibited low micromolar cytotoxicity against one or more of five human cancer cell lines.
Indexed BySCI ; IC
Language英语
WOS IDWOS:000329331200020
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/19248
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Kunming Fengshanjian Pharmaceut Corp, Kunming, Peoples R China
Recommended Citation
GB/T 7714
Liu, Ya-Ping,Zhao, Yun-Li,Feng, Tao,et al. Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(12):2322-2329.
APA Liu, Ya-Ping.,Zhao, Yun-Li.,Feng, Tao.,Cheng, Gui-Guang.,Zhang, Bao-Hong.,...&Luo, Xiao-Dong.(2013).Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens.JOURNAL OF NATURAL PRODUCTS,76(12),2322-2329.
MLA Liu, Ya-Ping,et al."Melosuavines A-H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens".JOURNAL OF NATURAL PRODUCTS 76.12(2013):2322-2329.
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