Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens
Liu, Xia1,2; Yang, Xing-Wei1,2; Chen, Chao-Qun1; Wu, Chun-Yan1; Zhang, Jing-Jing1,2; Ma, Jun-Zeng1; Wang, Huan1; Yang, Li-Xin1; Xu, Gang1
2013-09-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
Volume76Issue:9Pages:1612-1618
AbstractNine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B D (1-3) exhibited moderate inhibitory activity (IC50 5.8-17.9 mu M) against the tested tumor cell lines.
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000330331200014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/19247
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xia,Yang, Xing-Wei,Chen, Chao-Qun,et al. Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(9):1612-1618.
APA Liu, Xia.,Yang, Xing-Wei.,Chen, Chao-Qun.,Wu, Chun-Yan.,Zhang, Jing-Jing.,...&Xu, Gang.(2013).Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens.JOURNAL OF NATURAL PRODUCTS,76(9),1612-1618.
MLA Liu, Xia,et al."Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens".JOURNAL OF NATURAL PRODUCTS 76.9(2013):1612-1618.
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