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题名: Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.
作者: Zhou, Wen-Bing1, 2; Zeng, Guang-Zhi1; Xu, Hui-Min1, 2; He, Wen-Jun1; Tan, Ning-Hua1
刊名: MOLECULES
关键词: Aster tataricus ; shionane-type triterpenes ; astataricusones A-D ; astataricusol A ; anti-HBV
英文摘要: Five new shionane-type triterpenes, astataricusones A-D (compounds 1-4) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC50 value of 23.5 mu M, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC50 values of 18.6 and 40.5 mu M, and cytotoxicity on HepG 2.2.15 cells with CC50 values of 172.4 and 137.7 mu M, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC50 values of 2.7 and 30.7 mu M, respectively.
出版日期: 2013-12-01
卷号: 18, 期号:12, 页码:14585-14596
语种: 英语
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/19246
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Heilongtan 650201, Kunming, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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