Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.
Zhou, Wen-Bing1,2; Zeng, Guang-Zhi1; Xu, Hui-Min1,2; He, Wen-Jun1; Tan, Ning-Hua1
2013-12-01
发表期刊MOLECULES
卷号18期号:12页码:14585-14596
摘要Five new shionane-type triterpenes, astataricusones A-D (compounds 1-4) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC50 value of 23.5 mu M, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC50 values of 18.6 and 40.5 mu M, and cytotoxicity on HepG 2.2.15 cells with CC50 values of 172.4 and 137.7 mu M, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC50 values of 2.7 and 30.7 mu M, respectively.
关键词Aster Tataricus Shionane-type Triterpenes Astataricusones A-d Astataricusol a Anti-hbv
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000330315700009
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19246
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Heilongtan 650201, Kunming, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,et al. Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.[J]. MOLECULES,2013,18(12):14585-14596.
APA Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,He, Wen-Jun,&Tan, Ning-Hua.(2013).Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f..MOLECULES,18(12),14585-14596.
MLA Zhou, Wen-Bing,et al."Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.".MOLECULES 18.12(2013):14585-14596.
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