| Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f. | |
| Zhou, Wen-Bing1,2; Zeng, Guang-Zhi1; Xu, Hui-Min1,2; He, Wen-Jun1; Tan, Ning-Hua1 | |
| 2013-12-01 | |
| 发表期刊 | MOLECULES
 |
| 卷号 | 18期号:12页码:14585-14596 |
| 摘要 | Five new shionane-type triterpenes, astataricusones A-D (compounds 1-4) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC50 value of 23.5 mu M, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC50 values of 18.6 and 40.5 mu M, and cytotoxicity on HepG 2.2.15 cells with CC50 values of 172.4 and 137.7 mu M, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC50 values of 2.7 and 30.7 mu M, respectively. |
| 关键词 | Aster Tataricus Shionane-type Triterpenes Astataricusones A-d Astataricusol a Anti-hbv |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330315700009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/19246 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Heilongtan 650201, Kunming, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,et al. Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.[J]. MOLECULES,2013,18(12):14585-14596. |
| APA | Zhou, Wen-Bing,Zeng, Guang-Zhi,Xu, Hui-Min,He, Wen-Jun,&Tan, Ning-Hua.(2013).Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f..MOLECULES,18(12),14585-14596. |
| MLA | Zhou, Wen-Bing,et al."Astataricusones A-D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.".MOLECULES 18.12(2013):14585-14596. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| molecules-18-14585-v（387KB） | 开放获取 | CC BY-NC-ND | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论