Chemical constituents and evolutionally neutral DNA sequences of six samples of Cremanthodium lineare Maxim., collected in the Sichuan Province of China, were studied. Three samples produced furanoeremophilanes and the other three, eremophilan-8-ones. The chemotypes were found to be correlated with DNA sequence types, suggesting that the chemical diversity observed has a genetic origin. Production of furanoeremophilanes by a Cremanthodium species suggests an evolutionary relationship between Cremanthodium and Ligularia species, and possibly to related genera. (C) 2013 Elsevier Ltd. All rights reserved.
1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan 2.Rikkyo Univ, Dept Life Sci, Toshima Ku, Tokyo 1718501, Japan 3.Rikkyo Univ, Res Ctr Life Sci, Toshima Ku, Tokyo 1718501, Japan 4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan 5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan 6.Forestry & Forest Prod Res Inst, Shikoku Res Ctr, Kochi 7808077, Japan 7.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China