Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei
Zheng, Heng1,2; Chen, Qiong1,2; Zhang, Menke1; Lai, Yongji1; Lei, Liang1; Shu, Penghua1; Zhang, Jinwen2; Xue, Yongbo1; Luo, Zengwei1; Li, Yan3; Yao, Guangmin1; Zhang, Yonghui1
AbstractFifteen new ent-kaurane diterpenoids, compounds 1-15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu K alpha radiation. Compounds 1-15 were evaluated for their cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line. Compounds 1-10, 12, 14, and 15 showed broad-spectrum cytotoxicity, with compounds 1, 3, 6-10, 12, and 15 exhibiting more potent cytotoxicity than the positive control, cis-platin, with IC50 values ranging from 0.65 to 6.4 mu M.
Indexed BySCI ; IC
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000329331200011
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Document Type期刊论文
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Zheng, Heng,Chen, Qiong,Zhang, Menke,et al. Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(12):2253-2262.
APA Zheng, Heng.,Chen, Qiong.,Zhang, Menke.,Lai, Yongji.,Lei, Liang.,...&Zhang, Yonghui.(2013).Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei.JOURNAL OF NATURAL PRODUCTS,76(12),2253-2262.
MLA Zheng, Heng,et al."Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei".JOURNAL OF NATURAL PRODUCTS 76.12(2013):2253-2262.
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