Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei

doi:10.1021/np400600c

	Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei
	Zheng, Heng 1,2; Chen, Qiong 1,2; Zhang, Menke 1; Lai, Yongji 1; Lei, Liang 1; Shu, Penghua 1; Zhang, Jinwen 2; Xue, Yongbo 1; Luo, Zengwei 1; Li, Yan3 ; Yao, Guangmin 1; Zhang, Yonghui 1
	2013-12-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	76 期号:12 页码:2253-2262
摘要	Fifteen new ent-kaurane diterpenoids, compounds 1-15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu K alpha radiation. Compounds 1-15 were evaluated for their cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line. Compounds 1-10, 12, 14, and 15 showed broad-spectrum cytotoxicity, with compounds 1, 3, 6-10, 12, and 15 exhibiting more potent cytotoxicity than the positive control, cis-platin, with IC50 values ranging from 0.65 to 6.4 mu M.
DOI	10.1021/np400600c
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000329331200011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/19220
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Heng,Chen, Qiong,Zhang, Menke,et al. Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(12):2253-2262.
APA	Zheng, Heng.,Chen, Qiong.,Zhang, Menke.,Lai, Yongji.,Lei, Liang.,...&Zhang, Yonghui.(2013).Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei.JOURNAL OF NATURAL PRODUCTS,76(12),2253-2262.
MLA	Zheng, Heng,et al."Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei".JOURNAL OF NATURAL PRODUCTS 76.12(2013):2253-2262.

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